J. (Quim) Madrenas, MD, PhD, FCAHS
Chief Scientific Officer

Joaquin (Quim) Madrenas, MD, PhD, FCAHS

Investigator, The Lundquist Institute
Professor of Medicine, David Geffen School of Medicine at UCLA

As CSO, Dr. Madrenas leads LA BioMed’s overall scientific strategy, providing scientific leadership and direction for the Institute in biomedical and translational research, innovation, and career and collaboration development for our investigators.

Before joining LA BioMed, Dr. Madrenas was a Full Professor, Tier I Canada Research Chair in Human Immunology, and Chairman of the Department of Microbiology and Immunology at McGill University. He was the Founding Director of the Microbiome and Disease Tolerance Centre (MDTC) at McGill and Executive Director of the Canadian CIHR Human Immunology Network (CHIN). Additionally, Dr. Madrenas was the founding Director of the FOCIS Centre for Clinical Immunology and Immunotherapeutics in London, ON, the first FOCIS Centre of Excellence in Canada. Dr.  Madrenas is actively engaged in public education and community outreach in Science and History as illustrated by his recent engagement as a TEDx Montreal speaker.

Dr. Madrenas received an MD degree at the University of Barcelona, specialized in Nephrology and Transplantation at the University Autonoma of Barcelona. He obtained an MSc degree in Experimental Medicine under Dr. John B. Dossetor, and a PhD degree in Immunology under Dr. Phillip Halloran at the University of Alberta. Additionally, in 2011 he was inducted into the Canadian Academy of Health Sciences for his outstanding contributions in the health sciences.

Research Description

Dr. Madrenas' current research efforts focus on the identification, characterization and therapeutic development of immune modulatory compounds from the cell wall of S. aureus isolates using a combination of biochemical and immunological approaches as well as systems biology. These compounds from the cell wall of S. aureus serve as templates for novel anti-microbial and anti-inflammatory drugs. His other major research program is focused on mechanisms that regulate compartmentalization of mitochondrial membranes and how these mechanisms impact mitochondrial function and metabolic adaptation. Dr. Madrenas' previous discoveries include the different signaling patterns through the T cell antigen receptor, the mechanisms of CTLA-4 signaling, and identification of mechanisms of pathobiosis by Staphylococcus aureus.

Education

  • MD, 1982, University of Barcelona, Barcelona, Spain
  • Nephrologist, 1986, University Autónoma of Barcelona, Barcelona, Spain
  • MSc, 1988, University of Alberta, Edmonton, AB, Canada
  • PhD, 1992, University of Alberta, Edmonton, AB, Canada

Recent and/or Significant Publications

Chau TA, McCully ML, Brintnell W, An G, Kasper KJ, Vinés ED, Kubes P, Haeryfar SMM, McCormick JK, Cairns E, Heinrichs DE, Madrenas J. Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat Med. 2009 Jun;15(6):641-8. doi: 10.1038/nm.1965.
Frodermann V, Chau TA, Sayedyahossein S, Toth JM, Heinrichs DE, Madrenas J. A Modulatory IL-10 Response to Staphylococcal Peptidoglycan Prevents Th1 / Th17 Adaptive Immunity to S. aureus. J Infect Dis 2011; 204: 253.
Peres AG, Stegen C, Li J, Xu AQ, Levast B, Surette MG, Cousineau B, Desrosiers M, Madrenas J. Uncoupling of pro- and anti-inflammatory properties of Staphylococcus aureus. Infect Immun 2015; 83: 1587.
Miller MS, Rialdi A, Ho JSY, Tilove M, Martinez-Gil L, Moshkina NP, Peralta Z, Noel J, Melegari C, Maestre A, Mitsopoulos P, Heinz S, Benner C, Young J, Feagins AR, Madrenas J, Basler C, Fernandez-Sesma A, Becherel OJ, Lavin MF, van Bakel H, Marazzi I. Human senataxin suppresses the antiviral transcriptional response and controls viral biogenesis. at Immunol 16, 485–494 (2015).
Mitsopoulos P, Chang YH, Wai T, König T, Dunn SD, Langer T, Madrenas J. Stomatin-like Protein-2 is Required for In vivo Mitochondrial Respiratory Chain Supercomplex Formation and Optimal Cell Function. Mol Cell Biol 2015; 35: 1838.