Nih LR. Engineered Biomaterials for Tissue Regeneration of Innervated and Vascularized Tissues: Lessons Learned from the Brain. J Endod. 2020 Sep;46(9S):S101-S104. doi: 10.1016/j.joen.2020.06.036. PMID: 32950181.
Lina R. Nih, PhD
Investigator, The Lundquist Institute
Assistant Professor, Neurology Department, David Geffen School of Medicine at UCLA
Regenerative nanotechnologies for brain repair after stroke
Research DescriptionThe Nih Lab is a multi-disciplinary research team at the interface of neuroscience, vascular biology, and bioengineering. Dr. Nih and her team are primarily focused on elucidating the biological mechanisms of brain repair after stroke and investigating the role vessels play in the activation of endogenous repair mechanisms. The lab uses cutting-edge material engineering systems and pro-angiogenic nanotechnologies to promote brain repair and functional recovery after stroke.
Her research follows three major scientific directions:
1) Role of angiogenesis in brain repair and design of pro-angiogenic engineered therapeutic systems,
2) Hydrogel-assisted stem cell transplantation after stroke,
3) Design of immunomodulating technologies for stroke treatment.
- PhD, 2012, Neuroscience, University Paris V, France
Recent and/or Significant Publications
Nih LR, Gojgini S, Carmichael ST, Segura T. Dual-function injectable angiogenic biomaterial for the repair of brain tissue following stroke. Nat Mater. 2018 Jul;17(7):642-651. doi: 10.1038/s41563-018-0083-8. Epub 2018 May 21. PMID: 29784996; PMCID: PMC6019573.
Nih LR, Sideris E, Carmichael ST, Segura T. Injection of Microporous Annealing Particle (MAP) Hydrogels in the Stroke Cavity Reduces Gliosis and Inflammation and Promotes NPC Migration to the Lesion. Adv Mater. 2017 Aug;29(32):10.1002/adma.201606471. doi: 10.1002/adma.201606471. Epub 2017 Jun 26. PMID: 28650574; PMCID: PMC5595584.
Nih LR, Moshayedi P, Llorente IL, Berg AR, Cinkornpumin J, Lowry WE, Segura T, Carmichael ST. Engineered HA hydrogel for stem cell transplantation in the brain: Biocompatibility data using a design of experiment approach. Data Brief. 2016 Nov 24;10:202-209. doi: 10.1016/j.dib.2016.11.069. PMID: 27995155; PMCID: PMC5154973.
Nih LR, Deroide N, Leré-Déan C, Lerouet D, Soustrat M, Levy BI, Silvestre JS, Merkulova-Rainon T, Pocard M, Margaill I, Kubis N. Neuroblast survival depends on mature vascular network formation after mouse stroke: role of endothelial and smooth muscle progenitor cell co-administration. Eur J Neurosci. 2012 Apr;35(8):1208-17. doi: 10.1111/j.1460-9568.2012.08041.x. PMID: 22512253.