Nicholas Jendzjowsky, PhD
Investigator, The Lundquist Institute
Assistant Professor-in-Residence, Respiratory & Critical Care Physiology & Medicine, David Geffen School of Medicine at UCLA
Neural regulation of lung function, immunity and structure.
Research DescriptionDr. Jendzjowsky's laboratory focuses on the interplay between the autonomic nervous system and immune function in the lung. His goal is to develop a detailed mechanistic understanding of the molecular and cellular mechanisms of how nerves sense and interact with lung immune responses to allergens and bacteria. His hope is to gain new insight into this interaction with the goal of generating new therapeutics for asthma and bacterial lung infection by targeting the neural response. To this end, his laboratory utilizes, clinically relevant mouse and rat models of asthma and bacterial lung infection incorporating a variety of physiological, electrophysiological, microbiological, immunological and imaging approaches.
- BSc Kinesiology, 2005, University of Alberta
- MSc Rehabilitation Science, 2007, University of Alberta
- PhD, 2013, University of Alberta
Recent and/or Significant Publications
van Tilburg Bernardes, E., Pettersen, V.K., Gutierrez, M.W. et al. Intestinal fungi are causally implicated in microbiome assembly and immune development in mice. Nat Commun 11, 2577 (2020). doi:10.1038/s41467-020-16431-1
Jendzjowsky NG, Roy A, Barioni NO, et al. Preventing acute asthmatic symptoms by targeting a neuronal mechanism involving carotid body lysophosphatidic acid receptors. Nat Commun. 2018;9(1):4030. Published 2018 Oct 2. doi:10.1038/s41467-018-06189-y
Jendzjowsky NG, Kelly MM. The Role of Airway Myofibroblasts in Asthma. Chest. 2019;156(6):1254‐1267. doi:10.1016/j.chest.2019.08.1917