The study found that anakinra is safe and effective in improving neurobehavioral and functional outcomes for patients with Sanfilippo syndrome
Investigator(s):
Lynda Polgreen, MD, MS
The groundbreaking study was led by Lynda Polgreen, MD, MS, Investigator at The Lundquist Institute for Biomedical Innovation (TLI) and Associate Professor of Pediatrics at the David Geffen School of Medicine at UCLA, focused on using anakinra, a recombinant interleukin-1 receptor antagonist, on addressing the neuroinflammation component of Sanfilippo Syndrome.
A groundbreaking study published in the Journal of the American College of Emergency Physicians Open demonstrates that adhering to national pediatric care guidelines in emergency departments (EDs) saves children’s lives and is cost-effective, ranging from $4 to $48 per patient. This pivotal research by TLI’s Dr. Marianne Gausche-Hill offers compelling evidence about the financial feasibility of being "pediatric ready."
Investigator(s):
Marianne Gausche-Hill, MD, FACEP, FAAP, FAEMS
Becoming highly pediatric-ready could decrease child mortality rates by up to 76%
Marking a special milestone for medical research, Mary Burns, a 94-year-old trailblazer in the battle against COPD, made her return to The Lundquist Institute
Investigator(s):
Richard Casaburi, PhD, MD
Marking a special milestone for medical research, Mary Burns, a 94-year-old trailblazer in the battle against chronic obstructive pulmonary disease (COPD), made her return to The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (TLI). Fifteen years ago, Burns was the first to join the COPDGene study — a cutting-edge investigation seeking to unravel the complexities of COPD. As she walked through the doors of the Respiratory Research Center, it was more than just a routine check-up; it marked the inauguration of "Phase 4" of this pivotal study.
The proposed sensor has the potential to not only revolutionize COPD management but also to impact healthcare by incorporating wearable electronics into chronic disease management
Investigator(s):
Harry Rossiter, PhD
The U.S. Army Medical Research Acquisition Activity (USAMRAA) has awarded The Lundquist Institute (TLI) a four-year grant totaling $2,623,234. The research project is led by Dr. Harry Rossiter, an investigator at TLI and Professor at the David Geffen School of Medicine at UCLA. The project aims to develop wearable multiplex biosensors to monitor exacerbation risk in chronic obstructive pulmonary disease (COPD).
TLI Welcomes Four Incoming Board Members and Thanks Four Outgoing Members
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (TLI) has announced changes to its Board of Directors. The organization welcomes four distinguished incoming members and thanks the outgoing members for their invaluable contributions.
This study is poised to generate crucial new Down Syndrome cell lines to study genetic defects specific to Down Syndrome.
Investigator(s):
Denise Al Alam, PhD
The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center (TLI) has announced that The California Institute for Regenerative Medicine (CIRM), one of the world’s largest institutions dedicated to regenerative medicine, has awarded $1.5 million to TLI Investigator Denise Al Alam, PhD, to support research that aims to understand lung disease in individuals with Trisomy 21 (also known as Down Syndrome). Although Trisomy 21 impacts multiple organ systems, respiratory complications are a significant cause of death in children and adults with this genetic condition.
Dr. Yoshihara will investigate cutting-edge transcriptional gene regulation processes.
Investigator(s):
Eiji Yoshihara, PhD
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a division of the National Institutes of Health, has granted Eiji Yoshihara, PhD, a principal investigator at The Lundquist Institute (TLI) and assistant professor at the David Geffen School of Medicine at UCLA, a five-year grant totaling $3 million. This prestigious NIH R01 grant, known for its rigorous peer-review process, is dedicated to advancing stem cell therapy research for treating diabetes.
The project will take a pioneering approach to unraveling sensory and autonomic neurons in the overproduction of IgE in allergic asthma
Investigator(s):
Nicholas Jendzjowsky, PhD
In a significant stride for respiratory medicine, Lundquist Institute (TLI) investigator Nicholas Jendzjowsky, PhD, has been awarded a prestigious grant from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID). This grant, totaling $298,800, not only underscores TLI's commitment to pioneering research and excellence in respiratory medicine and exercise physiology but also recognizes Dr. Jendzjowsky's expertise and the importance of his research.
The Lundquist Institute is proud to announce that Wei Yan, MD, PhD, a distinguished professor at the David Geffen School of Medicine at UCLA and Lundquist investigator, has been appointed by the American Society of Andrology and the European Academy of Andrology as the new Editor-in-Chief of Andrology, the highly-respected journal in the field of reproductive medicine.
Investigator(s):
Wei Yan, MD, PhD
Dr. Yan's appointment to Andrology is a testament to his dedication to reproductive medicine. With extensive editorial experience, including his previous roles as co-editor-in-chief of Biology of Reproduction and Senior Editor of eLife, he has significantly advanced the understanding of fertility and infertility since joining The Lundquist Institute in 2020 to direct the National Center for Male Reproductive Epigenomics.
Lundquist Investigator Loren Miller, MD, MPH, will be honored with a 2024 Top Ten Clinical Research Achievement Award by the Clinical Research Forum (CR Forum) at a Las Vegas, NV ceremony, on April 2, 2024. Dr. Miller is an Investigator at TLI, Chief of Infectious Diseases at Harbor-UCLA Medical Center, and a Professor of Medicine at the David Geffen School of Medicine at UCLA.
Investigator(s):
Loren Miller, MD, MPH
The Top 10 Clinical Research Achievement Awards honor groundbreaking achievements in clinical research nationwide. The award recognizes the Protect Trial, a clinical trial jointly led by Dr. Miller and senior investigator Susan Huang, MD, MPH, Chancellor’s Professor at the University of California, Irvine. The Protect Trial involved nearly 14,000 residents in 28 California nursing homes in Los Angeles and Orange counties.