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Home Profiles Jerome I. Rotter, MD, FACP, FACMG, FAHA

Investigator, Translational Genomics
Distinguished Professor of Pediatrics and Human Genetics, David Geffen School of Medicine at UCLA
Executive Data Science Officer, The Lundquist Institute

Jerome I. Rotter, MD, FACP, FACMG, FAHA

Research Areas

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Research

Dr. Rotter’s research is in the genetics of common, complex diseases, those disorders that contribute to the major morbidity and mortality of the U.S. population. His work has utilized a variety of paradigms, from family-based, to case-control, to cohort, to pharmacogenetic studies, and from subclinical phenotypes, to candidate gene, to family based linkage, to genome-wide association, to large scale genome-wide genotyping and sequencing, to whole exome and whole genome sequencing, and to multi-omics.

He has contributed to our knowledge of the genetic basis of diabetes and insulin resistance, of blood pressure and hypertension, of lipid disorders and coronary artery disease, of cardiac rhythm disorders and sudden cardiac death, of obesity and fatty liver, and diabetic retinopathy, glaucoma, and retinopathy of prematurity, in multiple ethnic groups. The many genetic loci (chromosomal regions) identified are being utilized to generate multi-loci polygenic risk scores as tools to dissect disease etiology and to perform risk assessment in diverse populations and ethnic groups.

The ultimate goal of this work is to identify the optimal therapy and prevention for cardio metabolic, neurologic, and ocular disorders as a function of an individual’s genetic predispositions. Thus, this is the basis for precision/personalized medicine, especially in multi-ethnic populations that comprise the tapestry of the United States.

Biography

Jerome I. Rotter, M.D., F.A.C.P., F.A.C.M.G., F.A.H.A., is a medical geneticist/genetic epidemiologist. He is Director of the Institute for Translational Genomics and Population Sciences at the Lundquist Institute for Biomedical Innovation (formerly the Los Angeles Biomedical Research Institute) at Harbor-UCLA, Director of the Division of Genomic Outcomes in the Department of Pediatrics and Medicine, Harbor UCLA Medical Center (the southern campus of the UCLA School of Medicine), and a Distinguished Professor of Pediatrics and Human Genetics at UCLA.

He is a recipient of the Legends of Harbor-UCLA Medical Center Award, the Cedars-Sinai Pioneer in Medicine Award, the CHARGE Senior Leadership Award, and election to the CHARGE Hall of Fame. Dr. Rotter serves on the Steering Committees of major programs and consortia investigating the genomics of common cardio metabolic diseases, including TOPMed (NHLBI’s Trans-Omics for Precision Medicine), CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology), MESA (NHLBI’s Multi-Ethnic Study of Atherosclerosis, Chair, Genetics Committee), and DEFINE-T2D (NIDDK’s T2D Heterogeneity Consortium).

Publications

The following is a selected number of articles in 12 disease areas of the Genomics of Common Diseases actively studied by members of the Center for Translational Genomics.

Diabetes Mellitus (includes Type 1 DM, Type 2DM, Insulin Resistance, Insulin Secretion, Insulin Clearance, Fasting Glucose, Fasting Insulin, HgbA1C, and Diabetic Nephropathy)
  1. Zhao, W., Rasheed, A., Takkanen, E….. Guo, X… Taylor, K.D… Tai, E.S., Rotter, J.I., Chen, Y.-D.I….. Danesh, J., Voight, B., Saleheen, D.: Seventeen novel loci associated with type 2 diabetes and shared etiological pathways with coronary heart disease, Nature Genetics, 49(10):1450-1457, October, 2017. (e- published 9/4/2017, doi:10.1038/ng.3943) PMID: 28869590 PMCID: 5844224 
  2. Mahajan, A., Wessel, J., Willems, S.M….. Guo, X… Chen, Y.-D.I… Rich, S.S… Taylor, K.D… Goodarzi, M.O… Morris, A.P., Rotter, J.I., McCarthy, M.I.: Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes, Nature Genetics, 50(4):559-571, April, 2018. (e-published 4/9/2018, doi:10.1038/s41588-018-0084) PMID: 29632382 PMCID: 5898373
  3. Mahajan, A., Talium, D., Thurner, M….. Guo, X… Taylor, K.D… Meigs, J.B., Rotter, J.I., Marchini, J….. Morris, A.P., Boehnke, M., McCarthy, M.I.: Fine-mapping of an expanded set of type 2 diabetes loci to single- variant resolution using high-density imputation and islet-specific epigenome maps, Nature Genetics, 50(11):1505-1513, November, 2018. (e-published 10/8/2018, doi:10.1038/s41588- 018-0241-6) PMID: 30297969 PMCID: 6287706 
  4. Goodarzi, M.O., Palmer, N.D., Cui, J….. Guo, X., Chen, Y.-D.I., Taylor, K.D… Buchanan, T.A., Hsueh, W.A., Rotter, J.I.: Classification of type 2 diabetes genetic variants and a novel genetic risk score association with insulin clearance, Journal of Clinical Endocrinology and Metabolism, 105(4):1251-1260, April 1, 2020. (e-published 11/12/2019, doi:10.1210/clinem/dgz198) PMID: 31714576 PMCID: 7059988
  5. Chen, J., Spracklen, C.N., Marenne, G….. Rich, S.S… Taylor, K.D… Chen, Y.-D.I… Goodarzi, M.O… Guo, X… Zonderman, A.B., Rotter, J.I., Gloyn, A.L….. Wheeler, E., Morris, A.P., Barroso, I.: The trans-ancestral genomic architecture of glycaemic traits, Nature Genetics, 53(6):840-860, June, 2021. (e-published 5/31/2021, doi:10.1038/s41588-021-00852-9) PMID: 34059833 PMCID: 7610958 
  6. DiCorpo, D., LeClair, J., Cole, J.B….. Chen, Y.-D.I… Guo, X… Goodarzi, M.O… Florez, J.C., Rotter, J.I., Meigs, J.B., Dupuis, J., Udler, M.S.: Type 2 diabetes partitioned polygenic scores associated with disease outcomes in 454,193 individuals across 13 cohorts, Diabetes Care, 45(3):674-683, March 1, 2022. (e-published 1/27/2022, doi:10.2337/dc21-1395) PMID: 35085396 PMCID: 8918228
  7. Mahajan, A., Spracklen, C.N., Zhang, W….. Guo, X… Sofer, T… Goodarzi, M.O… Taylor, D.K… Rich, S.S… Chen, Y.-D.I… Boehnke, M., Rotter, J.I., McCarthy, M.I., Morris, A.P., on behalf of the DIAMANTE Consortium: Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation, Nature Genetics, 54(5):560-572, May, 2022. (e-published 5/12/2022, doi:10.1038/s41588-022-01058-3) PMID: 35551307 PMCID: 9179018
  8. Chen, Z.-Z., Pacheco, J.A., Gao, Y….. Guo, X… Taylor, K.D., Rich, S.S., Goodarzi, M.O., Rotter, J.I., Wilson, J., Clish, C., Gerszten, R.: Novel metabolite biomarkers of incident diabetes in African Americans revealed by the integration of nontargeted with targeted profiling, Diabetes, 71(11):2426-2437, November 1, 2022. (e-published 8/23/2022, doi:10.2337/db22-0033) PMID: 35998269 PMCID: 9630088
  9. Suzuki,K., Hatzikotoulas, K., Southam, L… Guo, X… Sofer, T…  Taylor, K.D… Ipp, E…. Chen, Y.-D.I., Rich, S.S… Goodarzi, M.O… Boehnke, M., Rotter, J.I., Vujkovic, M., Voight, B.F., Morris, A.P., Zeggini, E.: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology, Nature, 627(8003):347-357, March, 14, 2024. (doi:10.1101/2023-03-31.23287839) PMID: 38374256 PMCID: 10937372
  10. Ding, J., Nguyen, A.T., Lohman, K… Pankow, J.S., Rotter, J., Goodarzi, M.O… Rich, S.S… Jacobs Jr., D., Parks, J.S., Liu, Y.: LXR signaling pathway link cholesterol metabolism with risk for prediabetes and diabetes, Journal of Clinical Investigation, 134(10):e173278, May 15, 2024. (doi:10.1172/JCI173278) PMID: 38747290 PMCID: 11093600
  11. Li,Y., Chen, G.-C., Moon, J.-Y… Rotter, J.I., Taylor, K.D., Chen, Y.-D.I… Kaufman, J.D., Kaplan, R., Qi, Q.: Genetic subtypes of prediabetes, healthy lifestyle, and risk of type 2 diabetes, Diabetes, 73(7):1178-1187, July 1, 2024. (e-published 4/11/2024, doi: 10.2337/db23-0699) PMID: 38602922 PMCID: 11189833
  12. Sevilla-González, M., Smith, K., Wang, N… Goodarzi, M.O., Sladek, R., Rotter, J.I… Raghavan, S., Udler, M.S., Manning, A.K.: Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes, Nature Communications, 16(1):2569, March 15, 2025. (doi:10.1038/s41467-025-57452-7) PMID: 40089507
  13. Arruda, A.L., Bocher, O., Taylor, H.J., Cammann, D., Yoshiji, S., Yin, X., Zhao, C., Chen, J., Wood, A.C., Suzuki, K., Mercader, J.M., Spracklen, C.N., Meigs, J.B., Vujkovic, M., Smith, G.D., Rotter, J.I., Voight, B.F., Morris, A.P., Zeggini, E.: The effect of type 2 diabetes genetic predisposition on non-cardiovascular comorbidities, Nature Communications, 16(1):9042, October 10, 2025. (doi:10.1038/s41467-025-64927) PMID: 41073432 PMCID: 12514310
  14. Li, J., Hu, J., Yun, H… Guo, X… Wood, A.C…Gerszten, R.E… Clish, C.B… Rich, S.S., Rotter, J.I… Hu, F.B., Yu, B., Qi, Q: Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes, Nature Medicine, 32(2):660-670, February, 2026. (e-published 1/14/2026, doi: 10.1038/s41591-025-04105-8) PMID: 41535386 PMCID: 12920144
  15. Bocher, O., Arruda, A.L., Yoshiji, S., Zhao, C… Wood, A.C… Spracklen, C.N., Rotter, J.I., Morris, A.P., Zeggini, E.: Unravelling the molecular mechanisms causal to type 2 diabetes across global populations and disease-relevant tissues, Nature Metabolism, 8(2):506-520, February, 2026. (e-published 1/27/2026, doi:10.1038/s42255-025-01444-1) PMID: 41593238 PMCID: 12945685
  16. Huerta-Chagoya, A., Kim, J., Mandla, R… Orozco, L., Rotter, J.I., Sanghera, D… Sim, X., Mercader, J.M., Ng, M.C.Y., D-PRISM Consortium: Multi-ancestry polygenic scores for the prediction of type 2 diabetes and complications in diverse ancestries, Lancet Diabetes and Endocrinology, in press, 2026.
Cardiovascular Disease (includes CAD, Subclinical Atherosclerosis, Stroke, and Valvular Disease)
  1. Smith, J.G., Luk, K., Schulz, C.-A….. Budoff, M.J., Rotter, J.I., Cupples, L.A…Rich, S.S… Gudnason, V., O’Donnell, C.J., Post, W.S., Thanassoulis, G. for the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Extracoronary Calcium Working Group: Genetic elevated low- density lipoprotein cholesterol is associated with aortic valve calcification and incident aortic stenosis, Journal of the American Medical Association, 312(17):1764-1771, November 5, 2014. (e-published 10/26/2014, doi:10.1001/jama.2014.13959) PMID: 25344734 PMCID: 4280258 
  2. Dewey, F.E., Gusarova, V., Dunbar, R.L…. Guo, X., Rotter, J.I., Chen, Y.-D.I… Mellis, S.J., Gromada, J., Baras, A.: Genetic and pharmacologic inactivation of ANGPTL3 and atherosclerotic cardiovascular disease, New England Journal of Medicine, 377(3):211, July 20, 2017. (e- published 5/24/2017, doi:10.1056/NEJMoa1612790) PMID: 28538136 PMCID: 5800308 
  3. Khera, A.V., Chaffin, M., Zekavat, S.M… Taylor, K.D… Rich, S.S… Chen, Y.D.I… Talkowski, M.E., Rotter, J.I., Krumholz, H.M., Kathiresan, S.: Whole genome sequencing to characterize monogenic and polygenic contribution in patients hospitalized with early-onset myocardial infarction, Circulation, 139(13):1593-1602, March 26, 2019. (e-published 11/11/2018, doi:10.1161/CIRCULATIONAHA.118.035658) PMID: 30586733 PMCID: 6433484 
  4. Goodarzi, M.O., Rotter, J.I.: Genetic insights in the relationship between type 2 diabetes and coronary heart disease, Circulation Research, 126(11):1526-1548, May 22, 2020. (e-published 5/21/2020, doi:10.1161/CIRCRESAHA.119.316065) PMID: 32437307 PMCID: 7250006
  5. Fahed,A.C., Aragam, K.G., Hindy, G….. Chen, Y.-D.I… Rich, S.S., Rotter, J.I., Chowdhury, R….. Ellinor, P.T., Kathiresan, S., Khera, A.V.: Transethnic transferability of a genome-wide polygenic score for coronary artery disease – a multi-ancestry assessment, Circulation: Genomic and Precision Medicine, 14(1):e003092, February, 2021. (e-published 12/7/2020, doi:10.1161/CIRCGEN.120.003092) PMID: 33284643 PMCID: 7887053
  6. Al Rifai, M., Yao, J., Guo, X….. Budoff, M., Taylor, K.D., Lin, H.J., Rich, S.S… Greenland, P., Rotter, J.I., Virani, S.S.: Association of polygenic risk scores with incident atherosclerotic cardiovascular disease events among individuals with coronary artery calcium score of zero: The Multi-Ethnic Study of Atherosclerosis, Progress in Cardiovascular Diseases, 74:19-27, Sep-Oct, 2022. (e-published 8/8/2022, doi:10.1016/j.pcad.2022.08.003) PMID: 35952728 PMCID: 10240572
  7. Chen, H.Y., Dina, C., Small, A.M…… Budoff, M.J… Post, W.S., Rotter, J.I., Lathrop, M….. Clarke, R., Engert, J.C., Thanassoulis, G.: Genome-wide analyses highlight the roles of dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis, European Heart Journal, 44(21):1927-1939, June 1, 2023. (e-published 4/11/2023, doi;10.1093/eurheartj/ehad142) PMID: 37038246 PMCID: 10232274
  8. Kahn, S.S., Post, W.S., Guo, X….. Budoff, M.J… Mosley, J.D., Rotter, J.I., Greenland, P., Kavousi, M.: Coronary artery calcium score and polygenic risk score for the prediction of coronary heart disease event in the Multi-Ethnic Study of Atherosclerosis and the Rotterdam Study, Journal of the American Medical Association, 329(20):1768-1777, May 23, 2023. (doi:10.1001/jama.2023.7575) PMID: 37219552 PMCID: 1028141
  9. Kwak, S.H., Hernandez-Cancela, R.B., DiCorpo, D.A… Guo, X…. Chen, Y.-D.I., Taylor, K.D… Rich, S.S., Goodarzi, M.O… Liu, C.-T., Rotter, J.I., Meigs, J.B., on behalf of the Cohorts for Heart & Aging Research in Genomic Epidemiology (CHARGE) consortium: Time-to-event genome-wide association study for incident cardiovascular disease in people with type 2 diabetes mellitus, Diabetes Care, 47(6):1042-1047, June 1, 2024. (e-published 4/23/2024, doi:10.2337/dc23-2274) PMID: 38652672 PMCID: 11116923 
  10. Taylor, K.D., Wood, A.C., Guo, X., Herrington, D.M., Johnson, W.C., Post, W.S., Tracy, R.P., Rich, S.S., Rotter, J.I., Malik, S.: Metagenomics of cardiovascular events: The Multi-Ethnic Study of Atherosclerosis, Journal of the American Heart Association, 13(19):e035693, October, 2024. (e-published 9/30/2024) PMID: 39344648
  11. Whelton, S.P., Yao, J., Clish, C., Wood, A.C., Taylor, K.D., Blaha, M.J., Budoff, M., Marrero, N., Thanassoulis, G., Post, W.S., Guo, X., Rotter, J.I.: Association of polygenic risk scores with aortic valve calcium: The Multi-Ethnic Study of Atherosclerosis (MESA), Journal of the American Heart Association, in press, 2025.
  12. Sedaghati-khayat, B., Lin, H.J., Tan, J… Taylor, K.D., Li, X… Guo, X… Kavousi, M., van Rooij, J., Rotter, J.I.: Restricted vs genome-wide genetic risk scores for coronary artery disease, Journal of the American Heart Association, 15(4):e41398, February 17. (doi: 10.1161/jaha.125.041398) PMID: 41669951 
Ocular Disorders (includes Diabetic Retinopathy, Keratoconus, Macular Degeneration, Glaucoma, and Retinal Vasculature)
  1. Nannini, D., Torres, M., Chen, Y.-D.I., Taylor, K.D., Rotter, J.I., Varma, R., Gao, X.: African ancestry is associated with intraocular pressure in Latinos, Opthalmology, 123(1):102-8, January, 2016.(e-published 10/15/2015, doi:10.1016/j.ophtha.2015.08.042) PMID: 26477841 PMCID: 4695255
  2. Taylor, K.D., Guo, X., Zangwill, L.M….. Chen, Y.D., Ayyagari, R., Rotter, J.I., Weinreb, R.N. for the ADAGES III Genomics Study Group: Genetic architecture of POAG in individuals of African descent: The African Descent & Glaucoma Evaluation Study (ADAGES) III, Opthalmology, 126(1):38-48, 2019. (e-published 10/20/2018, doi:10.1016/j.ophtha.2018.10.031) PMID: 30352225 PMCID: 6309605
  3. Hauser, M.A., Allingham, R.R., Aung, T….. Taylor, K.D., Rotter, J.I., Wang, S.-H.J..… Chen, Y.-D.I… Guo, X… Koch, A.E.A., Fingert, J.H., Khor, C.C.: APBB2 is significant risk locus for primary open angle glaucoma in individuals of African ancestry, Journal of the American Medical Association, 322(17):1682-1691, November 5, 2019. (doi:10.1001/JAMA.2019.16161) PMID: 31688885 PMCID: 6865235
  4. Hardcastle, A.J., Liskova, P., Bykhovskaya, Y….. Li, X… Chen, Y.-D.I… Taylor, K.D… Wang, J.J., Rotter, J.I., Hewitt, A.W….. Hammond, C.J., Tuft, S.J., Hysi, P.G.: A multi-ethnic genome-wide association study for keratoconus identifies 36 loci and implicates collagen matrix integrity and cell differentiation pathways, Communications Biology, 4(1):266, March 1, 2021. (doi:10.1038/s42003-021-01784-0) PMID: 33649486 PMCID:7921564
  5. Li,X., Owen, L.A., Taylor, K.D… Chen, Y.-D.I… Guo, X., Eli Ipp… Chiang, M.F., Campbell, J.P., Rotter, J.I. on behalf of the i-ROP Consortium: Genome-wide association identifies novel ROP risk loci in a multi-ethnic cohort, Communications Biology, 7(1):107, January 17, 2024. (doi:10.1038/s42003-023-05743-9) PMID: 38233474 PMCID: 10794688
  6. Au, A., Bajar, B.T., Wong, B.M., Daskivich, L.P., Hosseini, H., Prasad, P.S.: Systemic and ocular outcomes in patients with young-onset type 2 diabetes, Journal of Diabetes and Its Complications, 2024, 38(2):108670, 2024. PMID: 38219336
Lipids (includes LDL, HDL, TG, Lp(a))
  1. Do, R., Willer, C.J., Schmidt, E.M..… Goodarzi, M.O… Chen, Y.-D.I… Rotter, J.I., Franks, P.W., Ripatti, S., Cupples, L.A., Sandhu, M.S., Rich, S.S., Boehnke, M., Deloukas, P., Mohlke, K.L., Ingelsson, E., Abecasis, G.R., Daly, M.J., Neale, B., Kathiresan, S.: Common variants associated with plasma triglycerides and risk for coronary artery disease, Nature Genetics, 45(11):1345-1352, November, 2013. (e-published 10/6/2013; doi: 10.1038ng.2795) PMID: 24097064 PMCID: 3904346  
  2. Li, X., Li, Z., Zhou, H….. Guo, X… Rich, S.S… NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Lipids Working Group, Rotter, J.I., Willer, C., Peloso, G.M., Natarajan, P., Lin, X.: Dynamic incorporation of multiple-in-silico functional annotations empowers rare variant association analysis in large- scale whole genome sequencing studies, Nature Genetics, 52(9):969-983, September, 2020. (e- published 8/24/2020, doi:10.1038/s4158-020-0676-4) PMID: 32839606 PMCID: 7483769 
  3. Graham, S.E., Clarke, S.l., Wu, K.-H…..  Li, X… Chen, Y.-D.I… Guo, X… Poulter, N., Rotter, J.I., Dantoft, T.M….. Deloukas, P., Sun, Y.V., Willer, C.:  The power of genetic diversity in genome-wide association studies of lipids, Nature, 600(7890):675-679, December 9, 2021. (doi:10.1038/s41586-021-04064-3) PMID: 34887591 PMCID: 8730582 
  4. Selvaraj, M.S., Li, X., Li, Z…… Guo, X… Li, X… Taylor, K.D… Chen, Y.-D.I… Rich, S.S., Willer, C., Rotter, J.I., Rader, D.J….. TOPMed Lipids Working Group, Peloso, G.M., Natarajan, P.: Whole genome sequencing analysis of blood lipid levels in >66,000 individuals, Nature Communications, 13(1):5995, October 11, 2022. (doi:10.1038/s41467-022-33510-7) PMID: 36220816 PMCID: 9553944
  5. Lee, M.P., Dimos, S., Raffield, L….. Guo, X… Rich, S.S… Tsai, M.Y., Rotter, J.I., Kooperberg, C….. Ballantyne, C.M., Avery, C.L., Raff, M.: Ancestral diversity in lipoprotein(a) studies help address evidence gaps, Open Heart Journal, 10(2):3002382, August, 2023. (doi:10.1136/openhrt-2023-002382) PMID: 37648373 PMCID: 10471864
  6. Selvaraj, M.S., Li, X., Li, Z., Van Buren, E… Guo, X… Taylor, K.D… Chen, Y.-D.I… Rich, S.S… Rotter, J.I., Lin, X., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Peloso, G.M., Natarajan, P.: The genetic architecture of low-density lipoprotein cholesterol across 1.23 billion variants, Genome Biology, 26(1):273, September 9, 2025. (doi:10.1186/s13059-025-03698-0) PMID: 40926209 PMCID: 12418676
Blood Pressure and Hypertension 
  1. Evangelou, E., Warren, H.R., Mosen-Ansorena, D….. Rose, L.M., Rotter, J.I., Rudan, I….. Guo, X… Wain, L.V., Elliott, P., Caufield, M.J.: Genetic analysis over one million people identifies 535 novel loci for blood pressure, Nature Genetics, 50(10):1412-1425, October, 2018. (e-published 9/17/2018, doi:10.1038/s41588-018-0205-x) PMID:30224653 PMCID: 6284793 
  2. Parcha, V., Pampana, A., Shetty, N.S..… Lin, H.J., Guo, X., Rich, S.S., Rotter, J.I., Li, P., Oparil, S., Arora, G., Arora, P.: Association of multi-ethnic genome-wide blood pressure polygenic risk score with adverse cardiovascular events, Circulation: Genomic and Precision Medicine, 15(6):e003946, December, 2022. (e-published 11/5/2022, doi:10.1161/CIRCGEN.122.003946) PMID: 36334310 PMCID: 9812363
  3. Kurniansyah, N., Goodman, M.O., Khan, A.T….. Guo, X… Lin, H.J… Chen, Y.-D.I… Rich, S.S… Levy, D., Rotter, J.I., Morrison, A.C., the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer, T.: Evaluating the use of blood pressure polygenic risk scores based on largest available GWAS across diversity background groups, Nature Communications, 14(1):3202, June 2, 2023. (doi:10.1038/s41467-023-38990-9) PMID: 37268629 PMCID: 10238525
  4. Keaton, J.M., Kamali, Z., Xie, T…. Rich, S.S… Lu, Y., Rotter, J.I., Guo, X… Munroe, P.B., Snieder, H., Warren, H.R. on behalf of the Million Veterans Program, Lifelines Cohort Study, CHARGE Consortium, and the ICBP Consortium: Genome-wide analysis of over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure, Nature Genetics, 56(5):778-791, May, 2024. (e-published 4/30/2024, doi:10.1038/s41588-024-01714-2) PMID: 38689001 PMCID: 11096100
  5. Rao, P., Keyes, M.J., Mi, M.Y…. Guo, X., Taylor, K.D., Rotter, J.I., Rich, S.S…. Sarzynski, M.A., Gerszten, R.E., Robbins, J.M.: Plasma proteomics of exercise blood pressure identifies TGFBR3 as a marker of incident hypertension, JAMA Cardiology, 9(8):713-722, August 1, 2024. (e-published 6/12/2024, doi:10.1001/jamacardio.2024.1397) PMID: 38865108 PMCID: 11170454
  6. Nagarajan, P., Winkler, T., Bentley, A.… Chen, Y.-D.I… Lin, H.J., Liu, P.Y… Rich, S.S… Sofer, T… Rotter, J.I… van Heemst, D., Redline, S., Noordam, R.: A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations, Molecular Psychiatry, 30(8):3660-3672, August, 2025. (e-published 4/4/2025, doi:10.1038/s41380-025-02954-w) PMID: 40181193 PMCID: 12683674
EKG and Arrhythmias (includes Atrial Fibrillation and Sudden Cardiac Death)
  1. Roselli,C., Chaffin, M.D., Weng, L.-C….. Chen, Y.-D.I… Guo, X… Lin, H.J… Rost, N., Rotter, J.I., Saba, S….. Taylor, K.D… Lubitz, S.A., Lunetta, K.L., Ellinor, P.T.: Multi-ethnic genome-wide association analyses for atrial fibrillation reveals 70 novel loci, Nature Genetics, 50(9):1225-1233, September, 2018. (e-published 6/11/2018, doi:10.1038/s41588-018- 0133-9) PMID: 29892015 PMCID: 6136836 
  2. Lin, H.J., Lan, Y.-T., Silka, M….. Chen, Y.-D.I., Taylor, K.D., Guo, X… Soyata, T., Rotter, J.I., Chien, T., Chou, P., Chang, R.-K.: Home use of a compact, 12-lead ECG recording system for newborns, Journal of Electrocardiography, 53:89-94, January, 2019. (doi:10.1016/j.jelectrocard.2019.01.086) PMID: 30716528 PMCID: 6458066
  3. Khera,A.V., Mason-Suares, H., VanDenburgh, M.J….. Taylor, K.D… Rich, S.S., Rotter, J.I., Lander, E.S….. Lebo, M., Albert, C.M., Kathiresan, S.: Gene sequencing for adult-onset sudden cardiac death, Journal of the American College of Cardiology, 74(21):2623-34, November 26, 2019. (doi:10.1016/j.jacc.2019 08.1060) PMID: 31727422 PMCID: 7067308
  4. Nauffal, V., Morrill, V.N., Jurgens, S.J….. Lin, H.J…Rich, S.S., Rotter, J.I., Soliman, E.Z….. Wilson, J.G., Ellinor, P.T., Lubitz, S.A.: Monogenic and polygenic contributions to QTc prolongation in the population, Circulation, 145(20:1524-1533, May 17, 2022. (e-published 4/7/2022, doi:10.1161/CIRCULATIONAHA.121.057261) PMID: 35389749 PMCID: 9117504
  5. Young, W.J., Haessler, J., Benjamins, J.-W….. Guo, X… Ribeiro, A.L.P., Rotter, J.I., Stricker, B.H….. Lin, H.J… Lambiase, P.D., Tereschenko, L.G., Munroe, P.B.: Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease, Nature Communications, 14(1):1411, March 14, 2023. (doi;10.1038/s41467-023-36997-2) PMID: 36918541 PMCID: 10015012 
  6. Roselli, C., Surakka, I., Olesen, M.S… Guo, X… Lin, H.J… Roden, D.M., Rotter, J.I., Sabatine, M.S… Willer, C., Stefansson, K., Ellinor, P.T.: Meta-analysis of genome-wide association and polygenic risk prediction for atrial fibrillation in more than 180,000 cases, Nature Genetics, 57(3):539-547, March, 2025. (doi:10.1038/s41588-024-02072-3) PMID: 40050429
Pharmacogenetics
  1. Postmus, I., Trompet, S., Deshmukh, H.A..… Li, X… Chen, Y.-D.I… Guo, X… Rotter, J.I., Cupples, L.A., Psaty, B.M., Colhoun, H.M., Hitman, G., Tardif, J.-C., Krauss, R.M., Jukema, J.W., Caulfield, M.J.: Pharmacogenetic meta- analysis of genome-wide scans of LDL cholesterol response to statins, Nature Communications, 5:5068, October 28, 2014. (doi:10.1038/ncomms6068) PMID: 25350695 PMCID: 4220464 
  2. Scott, R.A., Freitag, D.F., Li, L..… Riboli, E., Rotter, J.I., Saleheen, D..… Ehm, M.G., Wareham, N.J., Waterworth, D.M.: Genomic approach to therapeutic target validation identifies a glucose- lowering GLPIR variant protective for coronary heart disease, Science Translational Medicine, 8(341):341ra76, June 1, 2016. (doi:10.1126/scitranslmed.aad3744) PMID: 27252175 PMCID: 5219001
  3. Wei, W.-Q., Li, X., Feng, Q….. Wilke, R.A., Rotter, J.I., Stein, C.M., Momozawa, Y., Roden, D., Krauss, R.M., Denny, J.C.: LPA gene variants are associated with residual cardiovascular risk in patients receiving statins, Circulation, 138(17):1839-1849, October 23, 2018. (e-published 4/27/2018, doi:1161/CIRCULATIONAHA.117.031356) PMID: 29703846 PMCID: 6202211
  4. Gawrieh, S., Guo, X., Tan, J….. Taylor, K.D… Chen, Y.-D.I., Rotter, J.I., Chalasani, N., NASH Clinical Research Network: A pilot genome wide association study identifies promising loci associated with histological response and itching related to obeticholic acid in patients with nonalcoholic steatohepatitis, Hepatology Communications, 3(2):1571-1584, December, 2019. (doi: 10.1002/hep4.1439) PMID: 31832568 PMCID: 6887685
  5. Best, C.M., Li, X., Rotter, J.I… Taylor, K.D… Robinson-Cohen, C., de Boer, I.H., Kesterbaum, B.R.: Genetic variants associated with the biochemical response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis, Journal of Clinical Endocrinology and Metabolism, 110(10):2903-2914, September 15, 2025. (e-published 1/16/2025, doi:10.1210/clinem/dgaf025) PMID: 39815761 PMCID: 12448636
  6. Sheu, W.H.-H., Lee, C.-Y., Wang,Y.-W… Morris, A.P., Chen, Y.-D.I., Rotter, J.I.: Glycemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes, Diabetes, Obesity and Metabolism, 27(11):6323-6332, November, 2025. (e-published 8/22/2025, doi:10.111/dom.70023) PMID: 40842374 PMCID: 12515771
Anthropometry (includes Adiposity, Height)
  1. Akbari,P., Gilani, A., Sosina, O….. Chen, Y.-D.I., Rotter, J.I., Rader, D.J….. Baras, A., Ferreira, M.A.R., Lotta, L.A.: Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity, Science, 373(6550):eabf8683, July 2, 2021. (e-published 7/2/2021, doi:10.1126/science.abf8683) PMID: 34210852 PMCID: 10275396
  2. Weinschtein, P.,  Jain, D.P., Yengo, L….. Boerwinkle E., Rotter, J.I., O’Connell, J.R….. Rich, S.S… Guo, X., Chen, Y.-D.I… Laurie, C.C., Yang, J., Visscher, P.M.: Recovery of trait heritability from whole genome sequencing data, Nature Genetics, 54(3):263-273, March, 2022. (e-published 3/7/2022, doi:10.1038/s41588-021-00997-7) PMID: 35256806 PMCID: 9119698
  3. Yengo, L., Vedantam, S., Marouli, E….. Guo, X… Li, X… Taylor, K.D… Chen, Y.-D.I… Rosendaal, F.R., Rotter, J.I., Rudan, I….. Wood, A.R., Visscher, P.M., Hirschhorn, J.N.: A Saturated map of common genetic variants associated with human height from 5.4 million individuals of diverse ancestries, Nature, 610(7933):704-712, October, 2022. (e-published 10/12/2022, doi:10.1038/s41586-022-05275-y) PMID: 36224396 PMCID: 960586 
  4. Vargas, L.B., Lange, L.A., Ferrier, K….. Taylor, K.D… Rich, S., Rotter, J.I., Lange, E.M., Konigsberg, I.R.: Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis, International Journal of Obesity, 47(2):109-116, February, 2023. (e-published 12/3/2022, doi:10.1038/s41366-022-01240-x) PMID: 36463326 PMCID: 9990473
  5. Anwar, M.Y., Highland, H., Buchanan, V.L… Taylor, K.D…Gerszten, R.E., Clish, C.B., Goodarzi, M.O., Chen, Y.-D.I… Guo, X… Rotter, J.I., Rich, S.S., Liu, C.-T., Justice, A., North, K.: Machine-learning based clustering identifies obesity subgroups  with differential multi-omics profiles and metabolic patterns, Obesity, 32(11):2024-2034, November, 2024. (doi:10.1002/oby.24137) PMID: 39497627 PMCID: 11540333
  6. Smit, R.A.J., Wade, K.H., Hui, Q… Guo, X… Li, X… Taylor, K.D…  Chen, Y.-D.I… Rosendaal, F.R., Rotter, J.I., Rudan, I… Sun, Y.V., Berndt, S.I., Loos, R.J.F.: Polygenic scores to predict body mass index and obesity across populations and through the life course powered by data from 5.1 million individuals, Nature Medicine, 31(9):3151-3168, September, 2025. (e-published 7/21/2025, doi:10.1038/s41591-025-03827-z) PMID: 40691366 PMCID: 12443623
Fatty Liver (Metabolic Associated Steatotic Liver Disease)
  1. Barata, L., Feitosa, M.F., Bielak, L.F….. Guo, X… Chen, Y.-D.I… Budoff, M.J… Gudnason, V., Rotter, J.I., Fornage, M….. Peyser, P.A., Speilotes, E.K., Province, M.: Insulin resistance exacerbates genetic predisposition to NAFLD, Hepatology Communications, 3(7):894-907, April 18, 2019. (doi:10.1002/hep4.1353) PMID: 31334442 PMCID:6601321
  2. Vujkovic, M., Ramadas, S., Kimberly, R…..  Guo, X… Budoff, M… Lin, H.J., Chen, Y.-D.I., Taylor, K.D… Meigs, J.B., Rotter, J.I., Lynch, J.A….. Rader, D.J., Voight, B.F., Chang, K.-M.: A genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease in the Million Veteran Program, Nature Genetics, 54(6):761-771, June, 2022. (e-published 6/2/2022, doi:10.1038/s41588-022-01078-z) PMID: 35654975 PMCID: 10024253
  3. Chen, Y., Du, X., Kuppa, A….. Guo, X… Budoff, M.J… Chen, Y.-D.I., Taylor, K.D…Terry, J.G., Rotter, J.I., Wagenknecht, L.E….. Peyser, P.A., Palmer, N.D., Speliotes, E.K.: Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease, Nature Genetics, 55(10):1640-1650, October, 2023. (e-published 9/14/2023, doi:10.1038/s41588-023-01497-6) PMID: 37709864 PMCID: 10918428
  4. Moore, M.P., Wang, X., Kennelly, J.P… Guo, X… Mitsche, M.A., Rotter, J.I., Yates, K.P… Kono, N., Tontonoz, P., Tabas, I.: Low MBOAT7 expression, a genetic risk for MASH, promotes a pro-fibrotic pathway involving hepatocyte TAZ upregulation, Hepatology, 81(2):576-590, February 1, 2025. (e-published 5/22/2024, doi:10.1097/HEP. 00000000000000933) PMID: 38776184
  5. Hakim, A., Lin, K.-H., Schwantes-An, T.-H… Guo, X… Schwimmer, J.B., Rotter, J.I., Chalasani, N.P.: A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework, Hepatology Communications, 9(6):e0728, May 29, 2025. (doi:10.1097/HC9.00000000000000728) PMID: 40434633 PMCID: 12122170
  6. Gawrieh, S.M., Yao, J., Guo, X., Diehl, A.M., Rotter, J.I., Chalasani, N.P.: Biological age and its acceleration by Hannum clock interact with PNPLA3 rs738409 to increase the risk of MASLD, Clinical Gastroenterology and Hepatology, 24(4):1195-1197, April, 2026. (e-published 8/25/2025, doi:10.1016/j.cgh.2025.08.014) PMID: 40865626
Alzheimer’s (includes Cognition, Dementia)
  1. Lambert, J.-C., Ibrahim-Verbaas, C.A., Harold, D..… Bettens, K., Rotter, J.I., Brice, A..… Williams, J., Schellenberg, G.D., Amouyel, P.: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease, Nature Genetics, 45(12):1452-1458, December, 2013. (e-published 10/27/2013; doi:10.1038/ng.2802) PMID: 24162737 PMCID: 3896259  
  2. Davies, G., Armstrong, N., Bis, J.C….. Redmond, P., Rotter, J., Schmidt, H….. Taylor, K.D… Seshadri, S., Mosley, T.H., Deary, I.J.: Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE Consortium, Molecular Psychiatry, 20(2):183- 192, February, 2015. (e-published 2/3/2015, doi:10.1038/mp.2014.188) PMID: 25644384 PMCID: 4356746
  3. Davies, G., Lam, M., Harris, S.E….. Rose, R.J., Rotter, J.I., Roussos, P….. Taylor, K.D… Bressler, J., Lencz, T., Deary, I.J.: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function, Nature Communications, 9(1):2098, May 29, 2018. (doi:10.1038/S41467-018-4362-x) PMID: 29844566 PMCID: 5974083 
  4. Kunkle, B.W., Grenier-Boley, B., Vronskaya, M… Larson, E.B., Rotter, J.I., Bullido, M.J…Schellenberg, G.D., Lambert, J.-C., Pericak-Vance, M.A.: Genetic meta-analysis of diagnosedAlzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing, Nature Genetics, 51(3):414-430, March, 2019. (e-published 2/28/2019, doi:10.1038/s41588- 019-0358-2) PMID: 30820047 PMCID: 7473297 
  5. Paranjpe, M.D., Chaffin, M., Zahid, S.,  Ritchie, S., Rotter, J.I., Rich, S.S., Gerszten, R., Guo, X., Heckbert, S., Tracy, R., Danesh, J., Lander, E.S., Inouye, M., Kathiresan, S., Butterworth, A., Khera, A.V.: Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer’s disease, PLOS Genetics, 18(9):e1010294, September 1, 2022. (doi: 10.1371/journal.pgen.1010294) PMID: 36048760 PMCID: 9436054
  6. Tin, A., Fohner, A.E., Yang, Q….. Rich, S.S…. Guo, X… Mosley, T.H., Rotter, J.I., Gudnason, V.G…. Psaty, B.M., Seshadri, S., Fornage, M.: Circulating proteomic profiling of general cognitive function among middle-aged and older adults, Communications Biology, 6(1):1117, November 3, 2023. (doi:10.1038/s42003-023-05454-1) PMID: 37923804 PMCID: 10524811
  7. Fongang,  B., Sargurupremraj, M., Jian, X… Rich, S.S… Chasman, D.I., Rotter, J.I., Sattar, N.,. Kehoe, P.G., Weinstein, G., Seshadri, S. for the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE): A genome-wide association meta-analysis of all-cause and vascular dementia, Alzheimer’s & Dementia, 20(9):5973-5995, September, 2024. (e-published 7/24/2024) PMID: 39046104 PMCID: 111497727
  8. Domingo-Relloso, A., McGraw, K.E… Wood, A.C… Post, W.S., Rotter, J.I., Palta, P., Valeri, L., Hughes, T.M., Navas-Acien, A.:  Urinary metals, cognitive test performance and incident dementia by APOE4 allele carrier status in the Multi-Ethnic Study of Atherosclerosis (MESA), JAMA Network, 7(12):e2448286, December 2, 2024. (doi:10.1001/jamanetworkopen.2024.48286) PMID: 39621345 PMCID: 11612832 
  9. Sliz, E., Shin, J., Ahmad, S…. Barnes, J., Rotter, J.I., Debette, S…. Paus, T., Seshadri, S., Pausova, Z., for the neuroCHARGE Working Group: Distinct features in circulating metabolome associated with white matter hyperintensities in females and males, Circulation, 145(14):1040-1052, April 5, 2022. (e-published 1/20/2022, doi:10.1161/CIRCULATIONAHA.121.056892) PMID: 35050683 PMCID: 9645366
  10. Sedaghat, S., Park, S., Walker, R.F… Deo, R., Rotter, J.I., Wood, A.C… Lutsey, P.L., Guan, W., Prizment, A.: Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia, Communications Medicine, 5(1):353, August 14, 2025. (doi:10.1038/s43856-025-01096-y) PMID: 40813726 PMCID: 12354813
  11. Xue, D., Blue, E.E., Wood, A.C., Rotter, J.I., Fohner, A.E.: Risk score roulette: A cautionary tale of polygenic risk score reliability, Journal of Alzheimer’s Disease, 108(1):13872877251375098, September 9, 2025. (e-published 9/9/2025, doi:10.1177/13872877251375098) PMID: 40924585 PMCID: 40924585 PMCID: 12541115
  12. Sarnowski, C., Zhang, Y., Ammous, F… Wood, A.C… Rotter, J.I., Rich, S.S… Fornage, M., Seshadri, S., Morrison, A.C., on behalf of the TOPMed Diabetes working group and the TOPMed Neurocognitive working group: Associations of genetic scores related to insulin resistance with neurological traits ancestrally diverse cohorts from the Trans-Omics for Precision Medicine (TOPMed) program, Communications Biology, 8(1):1352, September 24, 2025. (doi:10.1038/s42003-025-08674-9) PMID: 40993182 PMCID: 12460837 
Sleep and Circadian Misalignment 
  1. Killick, R., Hoyos, C.M., Melehan, K., Dungan, G.C., Poh, J., Liu, P.Y.: Metabolic and hormonal effects of ‘catch-up’ sleep in men with chronic, repetitive, lifestyle-driven sleep restriction, Clinical Endocrinology, 83:498-507, October, 2015. PMID: 25683266 PMCID: 4858168
  2. Melehan, K., Hoyos, C.M., Hamilton, G.S., Wong, K.K., Yee, B.J., McLachlan, R.I., O’Meagher, S., Celermajer, D., Ng, M.K., Grunstein, R.R., Liu, P.Y.: Randomized trial of CPAP and vardenafil on erectile and arterial function in men with obstructive sleep apnea and erectile dysfunction, Journal of Clinical endocrinology and Metabolism, 103:1601-1611, 2018. (doi:10.1210/jc.2017-02389) PMID: 29409064 PMCID: 6457007
  3. Liu, P.Y., Irwin, M.R., Krueger, J.M., Gaddameedhi, S., Van Dongen, H.P.A.: Night shift schedule alters endogenous regulation of circulating cytokines, Neurobiology of Sleep and Circadian Rhythems, 10:100063, March, 2021. (doi:10.1016/j.nbscr.2021.100063) PMID: 33748539 PMCID: 7970107
  4. Liu, P.Y., Lawrence-Sidebottom, D., Piotrowska, K…. Auchus, R.J., Veldhuis, J.D., Van Dongen, H.P.A.: Restoring testosterone and cortisol balance during sleep restriction in men improves metabolic outcomes, Journal of Clinical Endocrinology and Metabolism, 106(9):e3436-48, August, 2021. PMID: 34043794 PMCID: 8660069
  5. Kelly, M.R., Yuen, F., Satterfield, B.C., Auchus, R.J., Gaddameedhi, S., Van Dongen, H.P.A., Liu, P.Y.: Endogenous diurnal patterns of adrenal and gonadal hormones during a 24-hour constant routine after simulated shiftwork, Journal of the Endocrine Society, 6(12):bvac153, September, 2022. PMID: 36330292 PMCID: 9620969
  6. Kurniansyah,N., Wallace, D.A., Zhang, Y….. Rich, S.S., Rotter, J.I., Gharib, S.A., Redline, S., Sofer, T.: An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling, Communications Biology, 6(1):125, January 31, 2023. (doi:10.1038/s42003-023-04520-y) PMID: 36721044 PMCID: 9889381
  7. Zhang, Y., Yu, B., Qi, Q., Azarbarzin, A., Chen, H., Shah, N.A., Ramos, A.R., Zee, P.C., Cao, J., Daviglus, M.L., Boerwinkle, E., Kaplan, R., Liu, P.Y., Redline, S., Softer, T.: Metabolomic profesiles of sleep-disordered breating are associated with hypertension and diabetes mellisu development: the HCHS/SOL, Nature Communications 15(1):1845, February 28, 2024. (doi:10.1038/s41467-024-46019-y) PMID: 38418471 PMCID: 10902315
  8. Wang,  Z., Wallace, D.A., Spitzer, B.W… Taylor, K.D., Rotter, J.I., Rich, S.S., Liu, P.Y… Redline, S., Isasi, C.R., Sofer, T.: Methylation risk score of C-reactive protein associates sleep health with related health outcomes, Communications Biology, 8(1):821, May 28, 2025. (doi:10.1038/s42003-025-08226-1) PMID: 40437222 PMCID: 12119824  
  9. Sorajja, N., Chung, J., Alcantara, C., Wassertheil-Smoller, S., Penedo, F.J., Ramos, A.R., Perreira, K.M., Daviglus, M.L., Suglia, S.F., Gallo, L.C., Liu, P.Y., Redline, S., Isasi, C.R., Sofer, T.A.: Sociodemographic index identifies sex-related effects on insomnia in the Hispanic Community Health Study/Study of Latinos, Sleep Advances, 5(1):zpae064, August, 2024. (doi:10.1093/sleepadvances/zpae064) PMID: 39314744 PMCID: 11417013
  10. Goodman, M.O., Faquih, T., Paz, V… Rotter, J.I., Taylor, K.D., Sofer, T… Redline, S., Saxena, R., Wang, H.: Genome-wide association analysis of composite sleep health scores in 413,904 individuals, Communications Biology, 8(1):115, January 24, 2025. (doi:10.1038/s42003-025-07514-0) PMID: 39856408 PMCID: 11760956
  11. Kurniansyah, N., Strausz, S.J., Chittoor, G… Kaplan, R., Rotter, J.I., Rich, S.S… Liu, P.Y…. Gottlieb, D.J., Sofer, T., FinnGen, The Trans-Omics in Precision Medicine Consortium, On Behalf of the VA Million Veteran Program: Polygenic risk scores for obstructive sleep apnea reveal pathways contributing to cardiovascular disease risk, EBioMedicine, 117:105790, June 4, 2025. (doi:10.1016/j.ebiom.2025.105790) PMID: 40472801
  12. Faquih, T., Potts, K., Yu, B… Taylor, K.D., Liu, P.Y… Rich, S.S., Clish, C.B., Rotter, J.I., Redline, S., Sofer, T., Wang, H.: Steroid biosynthesis and dietary related metabolites associated with excessive daytime sleepiness, EBioMedicine, 119:105881, September, 2025. (e-published 8/19/2025, doi:10.1016/j.ebiom.2025.105881) PMID: 40835488
Gene by Environment (Includes Diet, Alcohol, Smoking, Physical Education, Air Pollution) 
  1. Wood, A.C., Senn, M.K., Rotter, J.I.: Associations between avocado intake and lower rates of incident type 2 diabetes in US adults with Hispanic/Latino ancestry, Journal of Diabetes Mellitus, 13(2):116-119, April, 2023. (doi:10.4236/jdm.2023.132010) PMID: 37693693 PMCID: 10489295
  2. Wood, A.C., Goodarzi, M.O., Senn, M.K….. Tracy, R.P., Herrington, D.M., Rotter, J.I.: Associations between metabolomic biomarkers of avocado intake and glycemia in the Multi-Ethnic Study of Atherosclerosis (MESA), Journal of Nutrition, 153(10:2797-2807, October, 2023. (e-published 9/9/2023, doi:10.1016/j.tjnut.2023.07.013) PMID: 37562669 PMCID: 10925911
  3. Senn, M.K., Goodarzi, M.O., Ramesh, G….. Gardia, T.P., Rotter, J.I., Wood, A.C.: Associations between avocado intake and measures of glucose and insulin homeostasis in Hispanic individuals with and without Type 2 diabetes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), Nutrition, Metabolism, and Cardiovascular Diseases, 33(12):2428-2439, December, 2023. (e-published 8/18/2023, doi:10.1016/j.numecd.2023.08.002) PMID: 37798236 PMCID: 10842938
  4. Wood, A.C., Graca, G., Senn, M.K.….. Goodarzi, M.O., Tracy, R., Rotter, J.I., Herrington, D.: Untargeted metabolomic analysis investigating links between meat intake and markers of inflammation,  The American Journal of Clinical Nutrition, 118(5):989-999, November, 2023. (e-published 9/1/2023, doi:10.1016/j.ajcnut.2023.08.018) PMID: 37660929 PMCID: 10797554
  5. Li, Y., Wang, M., Liu, X….. Guo, X., Rotter, J.I., Smith, J.A….. Levy, D., Liu, C., Ma, J.: Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease, BMC Medicine, 21(1):433, November 15, 2023. (doi:10.1186/s12916-023-03149-2) PMID: 37968697 PMCID: 10652547
  6. Wood, A.C., A.C., Lee, D.J., Sheraidan, P… Rich, S.S., Chen, Y.-D.I., Herrington, D., Rotter, J.I., Goodarzi, M.O.: Metabolites link intake of a health diet to better insulin and glucose homeostasis in the Microbiome and Insulin Longitudinal Evaluation Study (MILES), Current Developments in Nutrition, 8(11):104462, September 26, 2024. (doi:10.1016/j.cdnut.2024.104462) PMID: 39624807 PMCID: 1160943