TLI Logo

Donate Today
Home Profiles Yii-Der Ida Chen, Ph.D.

Investigator, Translational Genomics
Professor of Pediatrics, David Geffen School of Medicine at UCLA
Director, Biochemistry, Molecular Phenotyping, and Microarray Laboratory

Yii-Der Ida Chen, PhD

Research Areas

, , ,
Research

Dr. Chen’s research broadly focuses on understanding the pathophysiology and etiology of insulin resistance and its associated metabolic and cardiovascular risks in humans. Her work has included extensive involvement with major multi-center studies such as the SAPPHIRe (Stanford Asian Pacific Program in Hypertension and Insulin Resistance), the IRAS (Insulin Resistance and Atherosclerosis) Family Study, and the PARC (Pharmacogenetic Network of Cardiovascular Risk Therapy), for which her laboratory served as the Central Biochemistry facility. She has been deeply engaged in pharmacogenetics research, participating in PARC, the PGRN (Pharmacogenetics Research Network), the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) pharmacogenetics working group, the International Genetics of Statin Therapy (GIST) consortium, and the Pharmacogenetics of Statin Therapy (POST) project.

Dr. Chen began serious engagement in genetics and genomics research in the mid-1990s, leveraging the uniquely strong environment in Human Genetics to address questions related to insulin resistance and its associated disorders, including diabetes, diabetic retinopathy, renal complications, dyslipidemia, hypertension, and both atrial and ventricular heart diseases involving macro- or micro-atherosclerosis and dysrhythmias. Her research has also expanded to obesity studies, reflecting the growing global pandemic, and to transcriptomics, with more than a decade of experience in microarray studies. She has conducted investigations across multiple ethnic groups, including African Americans, Hispanics, and Chinese.

Building on over a decade of collaborations with researchers in Taiwan, Dr. Chen co-founded the SAPPHIRe project with Dr. Victor Dzau while at Stanford, serving as the Central Biochemistry laboratory and as a member of the Steering Committee since its inception. This collaboration has led to joint efforts with Dr. Rao on the Taiwan SAPPHIRe Exome Sequencing grant and the NHLBI TOPMed program. She also co-founded the TAICHI Consortium, which has conducted Metabochip genotyping, GWAS, and whole exome sequencing on 13,000 Taiwanese subjects, serving as Chair of its Steering Committee, and established the TUDR (Taiwan U.S. Diabetic Retinopathy) Study.

Dr. Chen has been a long-term investigator in the MESA (Multi-Ethnic Study of Atherosclerosis) and leads a laboratory engaged in large-scale biochemistry and genomics research, collaborating with numerous multi-site studies including SAPPHIRe, IRAS Family, MESA, the nuMoM2b Heart Health Study, and CHS (Cardiovascular Health Study), for which her team provided methylation genotyping. Her laboratory also maintains a biorepository to support large-scale genomics projects. More recently, she has joined the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, representing the SAPPHIRe/THRV Taiwan-based hypertension-insulin resistance study, and, in collaboration with Drs. Rotter and Taylor, directs the genomics laboratory processing for all RURAL DNA samples, including DNA isolation and GWAS genotyping. She brings deep expertise in clinical epidemiology and laboratory research in multi-ethnic populations to her current and future research endeavors.

Biography

Dr. Ida Chen is a biochemist by training, earning both her M.S. (1971) and Ph.D. (1975) degrees from the University of Michigan. Her doctoral thesis focused on elucidating the effects of thyroid hormone on energy production in mitochondria, and she went on to complete postdoctoral training in reproductive endocrinology at the same institution in 1977.

That year, she joined the Division of Endocrinology and Metabolism in the Department of Medicine at Stanford University School of Medicine, where she pursued various metabolic studies after leaving the University of Michigan. At Stanford, she published extensively with Dr. Gerald Reaven in the fields of diabetes, insulin resistance and its related cardiovascular risk factors, and lipid metabolism, and was appointed Associate Professor.

In 2001, Dr. Chen was recruited by UCLA at Cedars-Sinai Medical Center as a full Professor. After 12 years of actively conducting clinical and laboratory research, she transitioned in 2013 to become one of the principal faculty members at the newly established Institute for Translational Genomics and Population Sciences on the Harbor-UCLA campus. There, she continues to participate actively at the Lundquist Institute (formerly LA BioMed) and in the Department of Pediatrics at Harbor-UCLA Medical Center, with a sustained commitment to teaching and research.

Publications
Diabetes Mellitus (Includes Type 1 DM, Type 2DM, Insulin Resistance, Insulin Secretion, Insulin Clearance, Fasting Glucose, Fasting Insulin, HgbA1C, and Diabetic Nephropathy)
  1. Zhao, W., Rasheed, A., Takkanen, E….. Guo, X… Taylor, K.D… Tai, E.S., Rotter, J.I., Chen, Y.-D.I….. Danesh, J., Voight, B., Saleheen, D.: Seventeen novel loci associated with type 2 diabetes and shared etiological pathways with coronary heart disease, Nature Genetics, 49(10):1450-1457, October, 2017. (e- published 9/4/2017, doi:10.1038/ng.3943) PMID: 28869590 PMCID: 5844224 
  2. Mahajan, A., Talium, D., Thurner, M….. Guo, X… Taylor, K.D… Meigs, J.B., Rotter, J.I., Marchini, J….. Morris, A.P., Boehnke, M., McCarthy, M.I.: Fine-mapping of an expanded set of type 2 diabetes loci to single- variant resolution using high-density imputation and islet-specific epigenome maps, Nature Genetics, 50(11):1505-1513, November, 2018. (e-published 10/8/2018, doi:10.1038/s41588- 018-0241-6) PMID: 30297969 PMCID: 6287706 
  3. Goodarzi, M.O., Palmer, N.D., Cui, J….. Guo, X., Chen, Y.-D.I., Taylor, K.D… Buchanan, T.A., Hsueh, W.A., Rotter, J.I.: Classification of type 2 diabetes genetic variants and a novel genetic risk score association with insulin clearance, Journal of Clinical Endocrinology and Metabolism, 105(4):1251-1260, April 1, 2020. (e-published 11/12/2019, doi:10.1210/clinem/dgz198) PMID: 31714576 PMCID: 7059988
  4. Chen, J., Spracklen, C.N., Marenne, G….. Rich, S.S… Taylor, K.D… Chen, Y.-D.I… Goodarzi, M.O… Guo, X… Zonderman, A.B., Rotter, J.I., Gloyn, A.L….. Wheeler, E., Morris, A.P., Barroso, I.: The trans-ancestral genomic architecture of glycaemic traits, Nature Genetics, 53(6):840-860, June, 2021. (e-published 5/31/2021, doi:10.1038/s41588-021-00852-9) PMID: 34059833 PMCID: 7610958 
  5. DeCorpo, D., LeClair, J., Cole, J.B….. Chen, Y.-D.I… Guo, X… Goodarzi, M.O… Florez, J.C., Rotter, J.I., Meigs, J.B., Dupuis, J., Udler, M.S.: Type 2 diabetes partitioned polygenic scores associated with disease outcomes in 454,193 individuals across 13 cohorts, Diabetes Care, 45(3):674-683, March 1, 2022. (e-published 1/27/2022, doi:10.2337/dc21-1395) PMID: 35085396 PMCID: 8918228
  6. Chen, Z.-Z., Pacheco, J.A., Gao, Y….. Guo, X… Taylor, K.D., Rich, S.S., Goodarzi, M.O., Rotter, J.I., Wilson, J., Clish, C., Gerszten, R.: Novel metabolite biomarkers of incident diabetes in African Americans revealed by the integration of nontargeted with targeted profiling, Diabetes, 71(11):2426-2437, November 1, 2022. (e-published 8/23/2022, doi:10.2337/db22-0033) PMID: 35998269 PMCID: 9630088
  7. Suzuki,K., Hatzikotoulas, K., Southam, L… Guo, X… Sofer, T…  Taylor, K.D… Ipp, E…. Chen, Y.-D.I., Rich, S.S… Goodarzi, M.O… Boehnke, M., Rotter, J.I., Vujkovic, M., Voight, B.F., Morris, A.P., Zeggini, E.: Genetic drivers of heterogeneity in type 2 diabetes pathophysiology, Nature, 627(8003):347-357, March, 14, 2024. (doi:10.1101/2023-03-31.23287839) PMID: 38374256 PMCID: 10937372
  8. Ding, J., Nguyen, A.T., Lohman, K… Pankow, J.S., Rotter, J., Goodarzi, M.O… Rich, S.S… Jacobs Jr., D., Parks, J.S., Liu, Y.: LXR signaling pathway link cholesterol metabolism with risk for prediabetes and diabetes, Journal of Clinical Investigation, 134(10):e173278, May 15, 2024. (doi:10.1172/JCI173278) PMID: 38747290 PMCID: 11093600
  9. Li,Y., Chen, G.-C., Moon, J.-Y… Rotter, J.I., Taylor, K.D., Chen, Y.-D.I… Kaufman, J.D., Kaplan, R., Qi, Q.: Genetic subtypes of prediabetes, healthy lifestyle, and risk of type 2 diabetes, Diabetes, 73(7):1178-1187, July 1, 2024. (e-published 4/11/2024, doi: 10.2337/db23-0699) PMID: 38602922 PMCID: 11189833
  10. Sevilla-González, M., Smith, K., Wang, N… Goodarzi, M.O., Sladek, R., Rotter, J.I… Raghavan, S., Udler, M.S., Manning, A.K.: Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes, Nature Communications, 16(1):2569, March 15, 2025. (doi:10.1038/s41467-025-57452-7) PMID: 40089507
Cardiovascular Disease (Includes CAD, Subclinical Atherosclerosis, Stroke, and Valvular Disease)
  1. Smith, J.G., Luk, K., Schulz, C.-A….. Budoff, M.J., Rotter, J.I., Cupples, L.A…Rich, S.S… Gudnason, V., O’Donnell, C.J., Post, W.S., Thanassoulis, G. for the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) Extracoronary Calcium Working Group: Genetic elevated low- density lipoprotein cholesterol is associated with aortic valve calcification and incident aortic stenosis, Journal of the American Medical Association, 312(17):1764-1771, November 5, 2014. (e-published 10/26/2014, doi:10.1001/jama.2014.13959) PMID: 25344734 PMCID: 4280258 
  2. Dewey, F.E., Gusarova, V., Dunbar, R.L…. Guo, X., Rotter, J.I., Chen, Y.-D.I… Mellis, S.J., Gromada, J., Baras, A.: Genetic and pharmacologic inactivation of ANGPTL3 and atherosclerotic cardiovascular disease, New England Journal of Medicine, 377(3):211, July 20, 2017. (e- published 5/24/2017, doi:10.1056/NEJMoa1612790) PMID: 28538136 PMCID: 5800308 
  3. Khera, A.V., Chaffin, M., Zekavat, S.M… Taylor, K.D… Rich, S.S… Chen, Y.D.I… Talkowski, M.E., Rotter,J.I., Krumholz, H.M., Kathiresan, S.: Whole genome sequencing to characterize monogenic and polygenic contribution in patients hospitalized with early-onset myocardial infarction, Circulation, 139(13):1593-1602, March 26, 2019. (e-published 11/11/2018, doi:10.1161/CIRCULATIONAHA.118.035658) PMID: 30586733 PMCID: 6433484 
  4. Goodarzi, M.O., Rotter, J.I.: Genetic insights in the relationship between type 2 diabetes and coronary heart disease, Circulation Research, 126(11):1526-1548, May 22, 2020. (e-published 5/21/2020, doi:10.1161/CIRCRESAHA.119.316065) PMID: 32437307 PMCID: 7250006
  5. Fahed,A.C., Aragam, K.G., Hindy, G….. Chen, Y.-D.I… Rich, S.S., Rotter, J.I., Chowdhury, R….. Ellinor,P.T., Kathiresan, S., Khera, A.V.: Transethnic transferability of a genome-wide polygenic score for coronary artery disease – a multi-ancestry assessment, Circulation: Genomic and Precision Medicine, 14(1):e003092, February, 2021. (e-published 12/7/2020, doi:10.1161/CIRCGEN.120.003092) PMID: 33284643 PMCID: 7887053
  6. Al Rifai, M., Yao, J., Guo, X….. Budoff, M., Taylor, K.D., Lin, H.J., Rich, S.S… Greenland, P., Rotter, J.I., Virani, S.S.: Association of polygenic risk scores with incident atherosclerotic cardiovascular disease events among individuals with coronary artery calcium score of zero: The Multi-Ethnic Study of Atherosclerosis, Progress in Cardiovascular Diseases, 74:19-27, Sep-Oct, 2022. (e-published 8/8/2022, doi:10.1016/j.pcad.2022.08.003) PMID: 35952728 PMCID: 10240572
  7. Chen, H.Y., Dina, C., Small, A.M…… Budoff, M.J… Post, W.S., Rotter, J.I., Lathrop, M….. Clarke, R., Engert, J.C., Thanassoulis, G.: Genome-wide analyses highlight the roles of dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis, European Heart Journal, 44(21):1927-1939, June 1, 2023. (e-published 4/11/2023, doi;10.1093/eurheartj/ehad142) PMID: 37038246 PMCID: 10232274
  8. Kahn, S.S., Post, W.S., Guo, X….. Budoff, M.J… Mosley, J.D., Rotter, J.I., Greenland, P., Kavousi, M.: Coronary artery calcium score and polygenic risk score for the prediction of coronary heart disease event in the Multi-Ethnic Study of Atherosclerosis and the Rotterdam Study, Journal of the American Medical Association, 329(20):1768-1777, May 23, 2023. (doi:10.1001/jama.2023.7575) PMID: 37219552 PMCID: 1028141
  9. Kwak, S.H., Hernandez-Cancela, R.B., DiCorpo, D.A… Guo, X…. Chen, Y.-D.I., Taylor, K.D… Rich, S.S., Goodarzi, M.O… Liu, C.-T., Rotter, J.I., Meigs, J.B., on behalf of the Cohorts for Heart & Aging Research in Genomic Epidemiology (CHARGE) consortium: Time-to-event genome-wide association study for incident cardiovascular disease in people with type 2 diabetes mellitus, Diabetes Care, 47(6):1042-1047, June 1, 2024. (e-published 4/23/2024, doi:10.2337/dc23-2274) PMID: 38652672 PMCID: 11116923 
  10. Taylor, K.D., Wood, A.C., Guo, X., Herrington, D.M., Johnson, W.C., Post, W.S., Tracy, R.P., Rich, S.S., Rotter, J.I., Malik, S.: Metagenomics of cardiovascular events: The Multi-Ethnic Study of Atherosclerosis, Journal of the American Heart Association, 13(19):e035693, October, 2024. (e-published 9/30/2024) PMID: 39344648
Ocular Disorders (Includes Diabetic Retinopathy, Keratoconus, Macular Degeneration, Glaucoma, and Retinal Vasculature)
  1. Taylor, K.D., Guo, X., Zangwill, L.M….. Chen, Y.D., Ayyagari, R., Rotter, J.I., Weinreb, R.N. for the ADAGES III Genomics Study Group: Genetic architecture of POAG in individuals of African descent: The African Descent & Glaucoma Evaluation Study (ADAGES) III, Opthalmology, 126(1):38-48, 2019. (e-published 10/20/2018, doi:10.1016/j.ophtha.2018.10.031) PMID: 30352225 PMCID: 6309605
  2. Hauser, M.A., Allingham, R.R., Aung, T….. Taylor, K.D., Rotter, J.I., Wang, S.-H.J..… Chen, Y.-D.I… Guo, X… Koch, A.E.A., Fingert, J.H., Khor, C.C.: APBB2 is significant risk locus for primary open angle glaucoma in individuals of African ancestry, Journal of the American Medical Association, 322(17):1682-1691, November 5, 2019. (doi:10.1001/JAMA.2019.16161) PMID: 31688885 PMCID: 6865235
  3. Hardcastle, A.J., Liskova, P., Bykhovskaya, Y….. Li, X… Chen, Y.-D.I… Taylor, K.D… Wang, J.J., Rotter, J.I., Hewitt, A.W….. Hammond, C.J., Tuft, S.J., Hysi, P.G.: A multi-ethnic genome-wide association study for keratoconus identifies 36 loci and implicates collagen matrix integrity and cell differentiation pathways, Communications Biology, 4(1):266, March 1, 2021. (doi:10.1038/s42003-021-01784-0) PMID: 33649486 PMCID: 7921564
  4. Li,X., Owen, L.A., Taylor, K.D… Chen, Y.-D.I… Guo, X., Eli Ipp… Chiang, M.F., Campbell, J.P., Rotter, J.I. on behalf of the i-ROP Consortium: Genome-wide association identifies novel ROP risk loci in a multi-ethnic cohort, Communications Biology, 7(1):107, January 17, 2024. (doi:10.1038/s42003-023-05743-9) PMID: 38233474 PMCID: 10794688
  5. Au, A., Bajar, B.T., Wong, B.M., Daskivich, L.P., Hosseini, H., Prasad, P.S.: Systemic and ocular outcomes in patients with young-onset type 2 diabetes, Journal of Diabetes and Its Complications, 2024, 38(2):108670, 2024. PMID: 38219336
Lipids
  1. Do, R., Willer, C.J., Schmidt, E.M..… Goodarzi, M.O… Chen, Y.-D.I… Rotter, J.I., Franks, P.W., Ripatti, S., Cupples, L.A., Sandhu, M.S., Rich, S.S., Boehnke, M., Deloukas, P., Mohlke, K.L., Ingelsson, E., Abecasis, G.R., Daly, M.J., Neale, B., Kathiresan, S.: Common variants associated with plasma triglycerides and risk for coronary artery disease, Nature Genetics, 45(11):1345-1352, November, 2013. (e-published 10/6/2013; doi: 10.1038ng.2795) PMID: 24097064 PMCID: 3904346  
  2. Li, X., Li, Z., Zhou, H….. Guo, X… Rich, S.S… NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium Lipids Working Group, Rotter, J.I., Willer, C., Peloso, G.M., Natarajan, P., Lin, X.: Dynamic incorporation of multiple-in-silico functional annotations empowers rare variant association analysis in large- scale whole genome sequencing studies, Nature Genetics, 52(9):969-983, September, 2020. (e- published 8/24/2020, doi:10.1038/s4158-020-0676-4) PMID: 32839606 PMCID: 7483769 
  3. Graham, S.E., Clarke, S.l., Wu, K.-H…..  Li, X… Chen, Y.-D.I… Guo, X… Poulter, N., Rotter, J.I., Dantoft, T.M….. Deloukas, P., Sun, Y.V., Willer, C.:  The power of genetic diversity in genome-wide association studies of lipids, Nature, 600(7890):675-679, December 9, 2021. (doi:10.1038/s41586-021-04064-3) PMID: 34887591 PMCID: 8730582 
  4. Selvaraj, M.S., Li, X., Li, Z…… Guo, X… Li, X… Taylor, K.D… Chen, Y.-D.I… Rich, S.S., Willer, C., Rotter, J.I., Rader, D.J….. TOPMed Lipids Working Group, Peloso, G.M., Natarajan, P.: Whole genome sequencing analysis of blood lipid levels in >66,000 individuals, Nature Communications, 13(1):5995, October 11, 2022. (doi:10.1038/s41467-022-33510-7) PMID: 36220816 PMCID: 9553944
  5. Lee, M.P., Dimos, S., Raffield, L….. Guo, X… Rich, S.S… Tsai, M.Y., Rotter, J.I., Kooperberg, C….. Ballantyne, C.M., Avery, C.L., Raff, M.: Ancestral diversity in lipoprotein(a) studies help address evidence gaps, Open Heart Journal, 10(2):3002382, August, 2023. (doi:10.1136/openhrt-2023-002382) PMID: 37648373 PMCID: 10471864
Blood Pressure and Hypertension 
  1. Evangelou, E., Warren, H.R., Mosen-Ansorena, D….. Rose, L.M., Rotter, J.I., Rudan, I….. Guo, X… Wain, L.V., Elliott, P., Caufield, M.J.: Genetic analysis over one million people identifies 535 novel loci for blood pressure, Nature Genetics, 50(10):1412-1425, October, 2018. (e-published 9/17/2018, doi:10.1038/s41588-018-0205-x) PMID: 30224653 PMCID: 6284793 
  2. Parcha, V., Pampana, A., Shetty, N.S..… Lin, H.J., Guo, X., Rich, S.S., Rotter, J.I., Li, P., Oparil, S., Arora, G., Arora, P.: Association of multi-ethnic genome-wide blood pressure polygenic risk score with adverse cardiovascular events, Circulation: Genomic and Precision Medicine, 15(6):e003946, December, 2022. (e-published 11/5/2022, doi:10.1161/CIRCGEN.122.003946) PMID: 36334310 PMCID: 9812363
  3. Kurniansyah, N., Goodman, M.O., Khan, A.T….. Guo, X… Lin, H.J… Chen, Y.-D.I… Rich, S.S… Levy, D., Rotter, J.I., Morrison, A.C., the NHLBI Trans-Omics in Precision Medicine (TOPMed) Consortium, Sofer, T.: Evaluating the use of blood pressure polygenic risk scores based on largest available GWAS across diversity background groups, Nature Communications, 14(1):3202, June 2, 2023. (doi:10.1038/s41467-023-38990-9) PMID: 37268629 PMCID: 10238525
  4. Keaton, J.M., Kamali, Z., Xie, T…. Rich, S.S… Lu, Y., Rotter, J.I., Guo, X… Munroe, P.B., Snieder, H., Warren, H.R. on behalf of the Million Veterans Program, Lifelines Cohort Study, CHARGE Consortium, and the ICBP Consortium: Genome-wide analysis of over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure, Nature Genetics, 56(5):778-791, May, 2024. (e-published 4/30/2024, doi:10.1038/s41588-024-01714-2) PMID: 38689001 PMCID: 11096100
  5. Nagarajan, Nagarajan, P., Winkler, T., Bentley, A.… Chen, Y.-D.I… Lin, H.J., Liu, P.Y… Rich, S.S… Sofer, T… Rotter, J.I… van Heemst, D., Redline, S., Noordam, R.: A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations, Molecular Psychiatry, in press, 2025. (e-published 4/4/2025, doi:10.1038/s41380-025-02954-w) PMID: 40181193
EKG and Arrhythmias (Includes Atrial Fibrillation and Sudden Cardiac Death)
  1. Roselli,C., Chaffin, M.D., Weng, L.-C….. Chen, Y.-D.I… Guo, X… Lin, H.J… Rost, N., Rotter, J.I., Saba, S….. Taylor, K.D… Lubitz, S.A., Lunetta, K.L., Ellinor, P.T.: Multi-ethnic genome-wide association analyses for atrial fibrillation reveals 70 novel loci, Nature Genetics, 50(9):1225-1233, September, 2018. (e-published 6/11/2018, doi:10.1038/s41588-018- 0133-9) PMID: 29892015 PMCID: 6136836 
  2. Lin, H.J., Lan, Y.-T., Silka, M….. Chen, Y.-D.I., Taylor, K.D., Guo, X… Soyata, T., Rotter, J.I., Chien, T., Chou, P., Chang, R.-K.: Home use of a compact, 12-lead ECG recording system for newborns, Journal of Electrocardiography, 53:89-94, January, 2019. (doi:10.1016/j.jelectrocard.2019.01.086) PMID: 30716528 PMCID: 6458066
  3. Khera,A.V., Mason-Suares, H., VanDenburgh, M.J….. Taylor, K.D… Rich, S.S., Rotter, J.I., Lander, E.S….. Lebo, M., Albert, C.M., Kathiresan, S.: Gene sequencing for adult-onset sudden cardiac death, Journal of the American College of Cardiology, 74(21):2623-34, November 26, 2019. (doi:10.1016/j.jacc.2019 08.1060) PMID: 31727422 PMCID: 7067308
  4. Young, W.J., Haessler, J., Benjamins, J.-W….. Guo, X… Ribeiro, A.L.P., Rotter, J.I., Stricker, B.H….. Lin, H.J… Lambiase, P.D., Tereschenko, L.G., Munroe, P.B.: Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease, Nature Communications, 14(1):1411, March 14, 2023. (doi;10.1038/s41467-023-36997-2) PMID: 36918541 PMCID: 10015012 
  5. Roselli, C., Surakka, I., Olesen, M.S… Guo, X… Lin, H.J… Roden, D.M., Rotter, J.I., Sabatine, M.S… Willer, C., Stefansson, K., Ellinor, P.T.: Meta-analysis of genome-wide association and polygenic risk prediction for atrial fibrillation in more than 180,000 cases, Nature Genetics, 57(3):539-547, March, 2025. (doi:10.1038/s41588-024-02072-3) PMID: 40050429
Pharmacogenetics
  1. Postmus, I., Trompet, S., Deshmukh, H.A..… Li, X… Chen, Y.-D.I… Guo, X… Rotter, J.I., Cupples, L.A., Psaty, B.M., Colhoun, H.M., Hitman, G., Tardif, J.-C., Krauss, R.M., Jukema, J.W., Caulfield, M.J.: Pharmacogenetic meta- analysis of genome-wide scans of LDL cholesterol response to statins, Nature Communications, 5:5068, October 28, 2014. (doi:10.1038/ncomms6068) PMID: 25350695 PMCID:4220464 
  2. Scott, R.A., Freitag, D.F., Li, L..… Riboli, E., Rotter, J.I., Saleheen, D..… Ehm, M.G., Wareham, N.J., Waterworth, D.M.: Genomic approach to therapeutic target validation identifies a glucose- lowering GLPIR variant protective for coronary heart disease, Science Translational Medicine, 8(341):341ra76, June 1, 2016. (doi:10.1126/scitranslmed.aad3744) PMID: 27252175 PMCID: 5219001
  3. Wei, W.-Q., Li, X., Feng, Q….. Wilke, R.A., Rotter, J.I., Stein, C.M., Momozawa, Y., Roden, D., Krauss, R.M., Denny, J.C.: LPA gene variants are associated with residual cardiovascular risk in patients receiving statins, Circulation, 138(17):1839-1849, October 23, 2018. (e-published 4/27/2018, doi:1161/CIRCULATIONAHA.117.031356) PMID: 29703846 PMCID: 6202211
  4. Gawrieh, S., Guo, X., Tan, J….. Taylor, K.D… Chen, Y.-D.I., Rotter, J.I., Chalasani, N., NASH Clinical Research Network: A pilot genome wide association study identifies promising loci associated with histological response and itching related to obeticholic acid in patients with nonalcoholic steatohepatitis, Hepatology Communications, 3(2):1571-1584, December, 2019. (doi: 10.1002/hep4.1439) PMID: 31832568 PMCID: 6887685
  5. Best, C.M., Li, X., Rotter, J.I… Taylor, K.D… Robinson-Cohen, C., de Boer, I.H., Kesterbaum, B.R.: Genetic variants associated with the biochemical response to Vitamin D3 in the Multi-Ethnic Study of Atherosclerosis, Journal of Clinical Endocrinology and Metabolism, in press, 2025. (e-published 1/16/2025, doi:10.1210/clinem/dgaf025) PMID: 39815761
Anthropometry (Includes Adiposity, Height)
  1. Akbari,P., Gilani, A., Sosina, O….. Chen, Y.-D.I., Rotter, J.I., Rader, D.J….. Baras, A., Ferreira, M.A.R., Lotta, L.A.: Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity, Science, 373(6550):eabf8683, July 2, 2021. (e-published 7/2/2021, doi:10.1126/science.abf8683) PMID: 34210852 PMCID: 10275396 
  2. Yengo, L., Vedantam, S., Marouli, E….. Guo, X… Li, X… Taylor, K.D… Chen, Y.-D.I… Rosendaal, F.R., Rotter, J.I., Rudan, I….. Wood, A.R., Visscher, P.M., Hirschhorn, J.N.: A Saturated map of common genetic variants associated with human height from 5.4 million individuals of diverse ancestries, Nature, 610(7933):704-712, October, 2022. (e-published 10/12/2022, doi:10.1038/s41586-022-05275-y) PMID: 36224396 PMCID: 960586 
  3. Vargas, L.B., Lange, L.A., Ferrier, K….. Taylor, K.D… Rich, S., Rotter, J.I., Lange, E.M., Konigsberg, I.R.: Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis, International Journal of Obesity, 47(2):109-116, February, 2023. (e-published 12/3/2022, doi:10.1038/s41366-022-01240-x) PMID: 36463326 PMCID: 9990473
  4. Anwar, M.Y., Highland, H., Buchanan, V.L… Taylor, K.D…Gerszten, R.E., Clish, C.B., Goodarzi, M.O., Chen, Y.-D.I… Guo, X… Rotter, J.I., Rich, S.S., Liu, C.-T., Justice, A., North, K.: Machine-learning based clustering identifies obesity subgroups  with differential multi-omics profiles and metabolic patterns,Obesity, 32(11):2024-2034, November, 2024. (doi:10.1002/oby.24137) PMID: 39497627 PMCID: 11540333
  5.  Smit, R.A.J., Wade, K.H., Hui, Q… Guo, X… Li, X… Taylor, K.D…  Chen, Y.-D.I… Rosendaal, F.R., Rotter, J.I., Rudan, I… Sun, Y.V., Berndt, S.I., Loos, R.J.F.: Polygenic scores to predict body mass index and obesity across populations and through the life course powered by data from 5.1 million individuals, Nature Medicine, in press, 2025. (e-published 7/21/2025, doi:10.1038/s41591-025-03827-z) PMID: 40691366
Fatty Liver (Metabolic Associated Steatotic Liver Disease)
  1. Barata, L., Feitosa, M.F., Bielak, L.F….. Guo, X… Chen, Y.-D.I… Budoff, M.J… Gudnason, V., Rotter, J.I., Fornage, M….. Peyser, P.A., Speilotes, E.K., Province, M.: Insulin resistance exacerbates genetic predisposition to NAFLD, Hepatology Communications, 3(7):894-907, April 18, 2019. (doi:10.1002/hep4.1353) PMID: 31334442 PMCID: 6601321
  2. Vujkovic, M., Ramadas, S., Kimberly, R…..  Guo, X… Budoff, M… Lin, H.J., Chen, Y.-D.I., Taylor, K.D… Meigs, J.B., Rotter, J.I., Lynch, J.A….. Rader, D.J., Voight, B.F., Chang, K.-M.: A genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease in the Million Veteran Program, Nature Genetics, 54(6):761-771, June, 2022. (e-published 6/2/2022, doi:10.1038/s41588-022-01078-z) PMID: 35654975 PMCID: 10024253
  3. Chen, Y., Du, X., Kuppa, A….. Guo, X… Budoff, M.J… Chen, Y.-D.I., Taylor, K.D…Terry, J.G., Rotter, J.I., Wagenknecht, L.E….. Peyser, P.A., Palmer, N.D., Speliotes, E.K.: Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease, Nature Genetics, 55(10):1640-1650, October, 2023. (e-published 9/14/2023, doi:10.1038/s41588-023-01497-6) PMID: 37709864 PMCID: 10918428
  4. Moore, M.P., Wang, X., Kennelly, J.P… Guo, X… Mitsche, M.A., Rotter, J.I., Yates, K.P… Kono, N., Tontonoz, P., Tabas, I.: Low MBOAT7 expression, a genetic risk for MASH, promotes a pro-fibrotic pathway involving hepatocyte TAZ upregulation, Hepatology, 81(2):576-590, February 1, 2025. (e-published 5/22/2024, doi:10.1097/HEP. 00000000000000933) PMID: 38776184
  5. Hakim, A., Lin, K.-H., Schwantes-An, T.-H… Guo, X… Schwimmer, J.B., Rotter, J.I., Chalasani, N.P.: A comprehensive evaluation of candidate genetic polymorphisms in a large histologically characterized MASLD cohort using a novel framework, Hepatology Communications, 9(6):e0728, May 29, 2025. (doi:10.1097/HC9.00000000000000728) PMID: 40434633 PMCID: 12122170
Alzheimer’s (Includes Cognition, Dementia)
  1. Lambert, J.-C., Ibrahim-Verbaas, C.A., Harold, D..… Bettens, K., Rotter, J.I., Brice, A..… Williams, J., Schellenberg, G.D., Amouyel, P.: Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease, Nature Genetics, 45(12):1452-1458, December, 2013. (e-published 10/27/2013; doi:10.1038/ng.2802) PMID: 24162737 PMCID: 3896259  
  2. Davies, G., Lam, M., Harris, S.E….. Rose, R.J., Rotter, J.I., Roussos, P….. Taylor, K.D… Bressler, J., Lencz, T., Deary, I.J.: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function, Nature Communications, 9(1):2098, May 29, 2018. (doi:10.1038/S41467-018-4362-x) PMID: 29844566 PMCID: 5974083 
  3. Kunkle, B.W., Grenier-Boley, B., Vronskaya, M… Larson, E.B., Rotter, J.I., Bullido, M.J…Schellenberg, G.D., Lambert, J.-C., Pericak-Vance, M.A.: Genetic meta-analysis of diagnosedAlzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing, Nature Genetics, 51(3):414-430, March, 2019. (e-published 2/28/2019, doi:10.1038/s41588- 019-0358-2) PMID: 30820047 PMCID: 7473297 
  4. Fongang,  B., Sargurupremraj, M., Jian, X… Rich, S.S… Chasman, D.I., Rotter, J.I., Sattar, N.,. Kehoe, P.G., Weinstein, G., Seshadri, S. for the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE): A genome-wide association meta-analysis of all-cause and vascular dementia, Alzheimer’s & Dementia, 20(9):5973-5995, September, 2024. (e-published 7/24/2024) PMID: 39046104 PMCID: 111497727
  5. Domingo-Relloso, A., McGraw, K.E… Wood, A.C… Post, W.S., Rotter, J.I., Palta, P., Valeri, L., Hughes, T.M., Navas-Acien, A.:  Urinary metals, cognitive test performance and incident dementia by APOE4 allele carrier status in the Multi-Ethnic Study of Atherosclerosis (MESA), JAMA Network, 7(12):e2448286, December 2, 2024. (doi:10.1001/jamanetworkopen.2024.48286) PMID: 39621345 PMCID: 11612832 
Sleep and Circadian Misalignment 
  1. Liu, P.Y., Lawrence-Sidebottom, D., Piotrowska, K…. Auchus, R.J., Veldhuis, J.D., Van Dongen, H.P.A.: Restoring testosterone and cortisol balance during sleep restriction in men improves metabolic outcomes, Journal of Clinical Endocrinology and Metabolism, 106(9):e3436-48, August, 2021. PMID: 34043794 PMCID: 8660069
  2. Kelly, M.R., Yuen, F., Satterfield, B.C., Auchus, R.J., Gaddameedhi, S., Van Dongen, H.P.A., Liu, P.Y.: Endogenous diurnal patterns of adrenal and gonadal hormones during a 24-hour constant routine after simulated shiftwork, Journal of the Endocrine Society, 6(12):bvac153, September, 2022. PMID: 36330292 PMCID: 9620969
  3. Kurniansyah,N., Wallace, D.A., Zhang, Y….. Rich, S.S., Rotter, J.I., Gharib, S.A., Redline, S., Sofer, T.: An integrated multi-omics analysis of sleep-disordered breathing traits implicates P2XR4 purinergic signaling, Communications Biology, 6(1):125, January 31, 2023. (doi:10.1038/s42003-023-04520-y) PMID: 36721044 PMCID: 9889381
  4. Wang,  Z., Wallace, D.A., Spitzer, B.W… Taylor, K.D., Rotter, J.I., Rich, S.S., Liu, P.Y… Redline, S., Isasi, C.R., Sofer, T.: Methylation risk score of C-reactive protein associates sleep health with related health outcomes, Communications Biology, 8(1):821, May 28, 2025. (doi:10.1038/s42003-025-08226-1) PMID: 40437222 PMCID: 12119824  
  5. Kurniansyah, N., Strausz, S.J., Chittoor, G… Kaplan, R., Rotter, J.I., Rich, S.S… Liu, P.Y…. Gottlieb, D.J., Sofer, T., FinnGen, The Trans-Omics in Precision Medicine Consortium, On Behalf of the VA Million Veteran Program: Polygenic risk scores for obstructive sleep apnea reveal pathways contributing to cardiovascular disease risk, EBioMedicine, 117:105790, June 4, 2025. (doi:10.1016/j.ebiom.2025.105790) PMID: 40472801
Gene by Environment (Includes Diet, Alcohol, Smoking, Physical Education, Air Pollution) 
  1. Wood,A.C., Senn, M.K., Rotter, J.I.: Associations between avocado intake and lower rates of incident type 2 diabetes in US adults with Hispanic/Latino ancestry, Journal of Diabetes Mellitus, 13(2):116-119, April, 2023. (doi:10.4236/jdm.2023.132010) PMID: 37693693 PMCID: 10489295
  2. Wood, A.C., Goodarzi, M.O., Senn, M.K….. Tracy, R.P., Herrington, D.M., Rotter, J.I.: Associations between metabolomic biomarkers of avocado intake and glycemia in the Multi-Ethnic Study of Atherosclerosis (MESA), Journal of Nutrition, 153(10:2797-2807, October, 2023. (e-published 9/9/2023, doi:10.1016/j.tjnut.2023.07.013) PMID: 37562669 PMCID: 10925911
  3. Li, Wang, M., Liu, X….. Guo, X., Rotter, J.I., Smith, J.A….. Levy, D., Liu, C., Ma, J.: Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease, BMC Medicine, 21(1):433, November 15, 2023. (doi:10.1186/s12916-023-03149-2) PMID: 37968697 PMCID: 10652547
  4. Senn, M.K., Goodarzi, M.O., Ramesh, G….. Gardia, T.P., Rotter, J.I., Wood, A.C.: Associations between avocado intake and measures of glucose and insulin homeostasis in Hispanic individuals with and without Type 2 diabetes: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), Nutrition, Metabolism, and Cardiovascular Diseases, 33(12):2428-2439, December, 2023. (e-published 8/18/2023, doi:10.1016/j.numecd.2023.08.002) PMID: 37798236 PMCID: 10842938
  5. Wood, A.C., Graca, G., Senn, M.K.….. Goodarzi, M.O., Tracy, R., Rotter, J.I., Herrington, D.: Untargeted metabolomic analysis investigating links between meat intake and markers of inflammation,  The American Journal of Clinical Nutrition, 118(5):989-999, November, 2023. (e-published 9/1/2023, doi:10.1016/j.ajcnut.2023.08.018) PMID: 37660929 PMCID: 10797554