B. Díaz, G. Shani, I. Pass, D. Anderson, M. Quintavalle and S.A. Courtneidge. Tks5-dependent, Nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Science Signaling Sep 15; 2(88): ra53. 2009.
Begoña Díaz, PhD
Investigator, The Lundquist Institute
Assistant Professor of Medicine, David Geffen School of Medicine at UCLA
Division of Medical Oncology Hematology, Harbor-UCLA Medical Center
Understanding and Targeting Cancer Cell Invasion and Metastasis
Research DescriptionResearch in Dr. Diaz’s laboratory focuses on understanding the cellular mechanisms that mediate the malignant behavior of cancer cells with the goal of utilizing this knowledge to uncover novel therapeutic targets to restrain metastasis. Dr. Diaz has investigated how the tumor microenvironmental conditions, including reactive oxygen species (ROS) and hypoxia promote cancer cell invasiveness. She has a deep understanding of the signaling mechanisms that regulate cancer biology, in particular those that mediate cell-cell communication and redox signaling in cancer cells.
- PhD, 1999, Autonomous University, Madrid, Spain
Recent and/or Significant Publications
D.A. Murphy, B. Díaz, P.A. Bromann, J.H. Tsai, Y. Kawakami, J. Maurer, R.A. Stewart, J.C. Izpisúa-Belmonte and S.A Courtneidge (2011). A Src-Tks5 pathway is required for neural crest migration during embryonic development. PLoS ONE 6(7): e22499. 2011.
J. M. Munson, L. Fried, S.A. Rowson, M.Y. Bonner, L. Karumbaiah, B. Díaz, S.A. Courtneidge, U. Knaus, D.J. Brat, J.L. Arbiser, RV. Bellamkonda. Anti-invasive adjuvant therapy with Imipramine Blue enhances chemotherapeutic efficacy against glioma. Science Translational Medicine 4,127ra36, 2012.
B. Díaz, A. Yuen, S. Iizuka, S. Higashiyama and S.A. Courtneidge. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. Journal of Cell Biology 201 (2), 279-292, 2013.
B. Díaz. Invadopodia detection and gelatin degradation assay. Bio-protocol. Vol 3, Issue 24. Dec. 20, 2013.