Nagendra Mishra, PhD
Investigator, The Lundquist Institute
Associate Professor of Medicine, David Geffen School of Medicine at UCLA
Antimicrobial Resistance and Lipidomics
Research DescriptionDr. Mishra's research focuses on the growing health issue of antimicrobial resistance. His lab studies adaptations associated with membrane lipids of Candida, Staphylococci, Enterococci and Streptococci that confer resistance to certain antibiotics in vitro and in vivo. He also discovered the significance of Staphylococcal carotenoid augmented membrane fluidity/rigidity and its implications in resistance to host defense peptides and in vivo virulence in an endocarditis model. Further understanding microbial adaptation to the host in the setting of anti-infective agents aims to open new doors to anti-infective strategies addressing the current challenge of conventional antibiotic resistance.
- PhD, University of Allahabad, India
Recent and/or Significant Publications
Kohler C, Proctor RA Bayer AS Yeaman MR, Lalk M, Engelmann S, Mishra NN. Proteomic and Membrane Lipid Correlates of Reduced Host Defense Peptide Susceptibility in a snoD Mutant. of Staphylococcus aureus. Antibiotics (Basel). 2019 Dec; 8(4): 169.
Zapata B, Alvarez DN, Farah S, Garcia-de-la-Maria C, Miro JM, Sakoulas G, Bayer AS, Mishra NN. 2018. Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies. Curr Microbiol. 2018 Aug;75(8):1062-1067. doi: 10.1007/s00284-018-1491-3. Epub 2018 Apr 12.
Xiong YQ, Yang SJ, Tong SY, Alvarez DN, Mishra NN. The role of Staphylococcal arotenogenesis in resistance to host defense peptides and in vivo virulence in experimental endocarditis model. Pathog Dis. 2015 Oct; 73(7): ftv056.
Mishra NN, TT Tran, R Seepersaud, C.Garcia-de-la-Maria, K Faull, A Yoon, R Proctor, JM Miro, MJ Rybak, AS Bayer, CA Arias, PM Sullam. Perturbations of phosphatidate cytidylyltransferase (cdsA) mediate daptomycin resistance in Streptococcus mitis by a novel mechanism. Antimicrobial Agents and Chemother. 61(4). pii: e02435-1, March 2017. PMID: 28115347. PMCID: PMC5365703.
Mishra NN, Bayer AS. 2013. Correlation of cell membrane lipid profiles with daptomycin resistance in methicillin-resistant Staphylococcus aureus.Antimicrob Agents Chemother. 2013 Feb;57(2):1082-5.