Hua Wang, PhD
Investigator, The Lundquist Institute
Assistant Professor of Medicine, David Geffen School of Medicine at UCLA
Contact
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The Interplay between DNA damage repair and differentiation regulation during tumorigenesis
Research Description
1) To identify the BRCA1/BRCA2-containing machinery to orchestrate DNA damage repair and differentiation regulation in breast epithelial cells and others;2) To identify damage-induced stem cells during the tissue homeostasis and cancer development;
3) To identify new therapeutic targets through the synthetic lethality screen by targeting the DNA damage repair pathways. We aim to elucidate the molecular and cellular mechanisms during the tissue regeneration and tumor development.
Theme Groups
Research Interests
Education
- PhD, 2008, Genetics and Human Oncology, University of Wisconsin-Madison
Recent and/or Significant Publications
Wang H, Xiang D, Liu B, et al. Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer. Cell. 2019;178(1):135-151.e19. doi:10.1016/j.cell.2019.06.002
Li AG, Murphy EC, Culhane AC, et al. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. Proc Natl Acad Sci U S A. 2018;115(41):E9600-E9609. doi:10.1073/pnas.1807112115
Wang H, Bierie B, Li AG, et al. BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. Mol Cell. 2016;63(2):277-292. doi:10.1016/j.molcel.2016.05.038
Wang H, Teske D, Tess A, et al. Identification of novel modifier loci of Apc Min affecting mammary tumor development. Cancer Res. 2007;67(23):11226-11233. doi:10.1158/0008-5472.CAN-07-2487