Alan Waring, PhD
Investigator, The Lundquist Institute
Professor of Medicine, David Geffen School of Medicine at UCLA
Contact
Email
Protein Engineering
Research Description
The current research focus of Dr. Waring's lab is the study of membrane protein-lipid interactions involved in antimicrobial host defense, pulmonary surfactant activity, and the fusion of enveloped viruses. These studies aim to provide a solid foundation for molecular therapies in diseases such as the respiratory distress syndrome, as well as bacterial, fungal and viral infections.Theme Groups
Research Interests
Education
- PhD, 1974, University of California, Los Angeles
Recent and/or Significant Publications
Chaili S, Cheung AL, Bayer AS, et al. The GraS Sensor in Staphylococcus aureus Mediates Resistance to Host Defense Peptides Differing in Mechanisms of Action. Infect Immun. 2015;84(2):459–466. Published 2015 Nov 23. doi:10.1128/IAI.01030-15
Chakraborty A, Hui E, Waring AJ, Dhar P. Combined effect of synthetic protein, Mini-B, and cholesterol on a model lung surfactant mixture at the air-water interface. Biochim Biophys Acta. 2016;1858(4):904–912. doi:10.1016/j.bbamem.2016.01.008
Micewicz ED, Sharma S, Waring AJ, Luong HT, McBride WH, Ruchala P. Bridged Analogues for p53-Dependent Cancer Therapy Obtained by S-Alkylation. Int J Pept Res Ther. 2016;22(1):67–81. doi:10.1007/s10989-015-9487-3
Waring AJ, Gupta M, Gordon LM, Fujii G, Walther FJ. Stability of an amphipathic helix-hairpin surfactant peptide in liposomes. Biochim Biophys Acta. 2016;1858(12):3113–3119. doi:10.1016/j.bbamem.2016.09.014
Henderson JM, Waring AJ, Separovic F, Lee KYC. Antimicrobial Peptides Share a Common Interaction Driven by Membrane Line Tension Reduction. Biophys J. 2016;111(10):2176–2189. doi:10.1016/j.bpj.2016.10.003