Omid Khorram, MD, PhD
Investigator, The Lundquist Institute
Professor In- Residence of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA
Chief, Division of Reproductive Endocrinology and Infertility, Harbor-UCLA Medical Center
Contact
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Role of miRNA in leiomyoma pathogenesis; Vascular Mechanisms underlying programmed hypertension
Research Description
Dr. Khorram utilizes a multidisciplinary approach that includes genomics, cell biology, biochemistry, and molecular biology to study the role of non-coding RNAs in programmed hypertension and in the pathogenesis of leiomyoma. His laboratory was one of the first to demonstrate the role of miRNAs as an epigenetic mechanism for programming vascular extracellular matrix composition and adult onset vascular stiffening in response to maternal under-nutrition. A second area of research focus is understanding the role of non-coding RNAs and therapies to correct their aberrant expression in leiomyoma.Theme Groups
Research Interests
Education
- BA, 1979, University of California at Berkeley
- PhD, 1984, University of Texas Southwestern Medical School
- MD, 1989, Texas Tech University Health Science Center
Recent and/or Significant Publications
O Khorram, T Chuang, WJ Pearce. Long-term effects of maternal undernutrition on offspring carotid artery remodeling: Role of miR-29c. J of DOHAD 6(4):342-9 (2015).
TD Chuang, O Khorram. Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma. Fertil Steril. 105 (1):236-45 (2016).
TD Chuang, O Khorram. Tranilast inhibits genes functionally involved in cell proliferation, fibrosis and epigenetic regulation and epigenetically induces miR-29c expression in leiomyoma cells. Reprod Sci 24:1253-1263 (2017).
TD Chuang, O Khorram. Expression Profiling of lncRNAs, miRNAs and mRNAs and Their Differential Expression in Leiomyoma Using Next Generation RNA Sequencing. Reprod Sci. 2018 Feb;25(2):246-255. doi: 10.1177/1933719117711265. Epub 2017 Jun 7.
TD Chuang, O Khorram. Glucocorticoids Regulate miR-29c levels in Vascular Smooth Muscle Cells through Transcriptional and Epigenetic Mechanisms. Life Sci. 2017 Oct 1;186:87-91. doi: 10.1016/j.lfs.2017.08.007. Epub 2017 Aug 8.
TD Chuang, O Khorram. Expression Profiling of lncRNAs, miRNAs and mRNAs and Their Differential Expression in Leiomyoma Using Next Generation RNA Sequencing. Reprod Sci. 2018 Feb;25(2):246-255. doi: 10.1177/1933719117711265. Epub 2017 Jun 7.
TD Chuang, O Khorram. Glucocorticoids Regulate miR-29c levels in Vascular Smooth Muscle Cells through Transcriptional and Epigenetic Mechanisms. Life Sci. 2017 Oct 1;186:87-91. doi: 10.1016/j.lfs.2017.08.007. Epub 2017 Aug 8.
Complete List of Published Work at