Research
Dr. Lewis’s research focuses on the statistical design, implementation, oversight, and analysis of innovative clinical trials. His expertise includes adaptive and Bayesian clinical trials including platform trials. He is involved in the design and leadership of multiple national and international adaptive and platform clinical trials funded by both national funders, e.g., NIH, and industry partners.
Biography
Dr. Lewis is a Professor of Emergency Medicine at the David Geffen School of Medicine at UCLA and a Senior Medical Scientist at Berry Consultants, LLC, a group that specializes in innovative clinical trial design. Dr. Lewis is the senior statistical editor for JAMA and editor of the JAMA series entitled “JAMA Guide to Statistics and Methods.” His expertise centers on adaptive and Bayesian clinical trials, including platform trials; general clinical research methodology; data and safety monitoring boards, and the oversight of clinical trials. Dr. Lewis was elected to membership in the National Academy of Medicine in 2009.
Dr. Lewis was formerly the Chair of the Department of Emergency Medicine at Harbor-UCLA Medical Center and a Senior Physician in the Los Angeles County Department of Health Services. He has previously served as a member of the Blood Products Advisory Committee of the US Food and Drug Administration, Center for Biologics Evaluation and Research (CBER), the Medicare Evidence Development & Coverage Advisory Committee of the Centers for Medicare & Medicaid Services, and on multiple consensus committees of the National Academy of Medicine. He has chaired data and safety monitoring boards (DSMBs) for numerous federally funded, industry-sponsored, and multinational clinical trials. Dr. Lewis has served as a content reviewer for many peer reviewed journals. He has authored or coauthored approximately 300 original research publications, reviews, editorials, and chapters.
Dr. Lewis has served as a grant reviewer for the Agency for Healthcare Research and Quality (AHRQ), the Canadian Institutes of Health Research (CIHR), the Centers for Disease Control and Prevention (CDC), the UK Medical Research Council (MRC), the National Cancer Institute of France, the National Institutes of Health (NIH), the Patient Centered Outcomes Research Institute (PCORI), the Wellcome Trust and other foundations.
During the US COVID-19 epidemic, Dr. Lewis served as the Director of Covid-19 Demand Modeling for the Los Angeles County Department of Health Services, leading a multidisciplinary team developing epidemiological prediction models to aid in hospital preparedness and response.
Dr. Lewis is a Past President of the Society for Academic Emergency Medicine (SAEM) and served on the Board of Directors for the Society for Clinical Trials. He is a fellow of the American Statistical Association and the Society for Clinical Trials. Dr. Lewis received his PhD in Biophysics and his MD from Stanford University.