Wang S, Hirschberg R. Bone morphogenetic protein-7 signals opposing transforming growth factor beta in mesangial cells. The Journal of Biological Chemistry 279, 23200-23206, 2004 May 28.
Raimund Hirschberg, MD
Investigator, The Lundquist Institute
Professor of Medicine, David Geffen School of Medicine at UCLA
Director, Acute Hemodialysis Unit, Harbor-UCLA Medical Center
Research DescriptionRenal fibrogenesis is the downstream biological process is virtually any renal disease causing renal insufficiency and, finally, complete renal failure. Dr. Hirschberg studies the pathways that contribute to fibrosis in the kidney. He found that fibroblast proliferation is regulated by TGFb pathway. A separate project in the lab examines the regulation of renal intercalated cells by TGFb and BMP.
- MD, 1979, Free University of Berlin, School of Medicine, Berlin, Germany
Recent and/or Significant Publications
Wang S, de Caestecker M, Kopp J, Mitu G, Lapage J, Hirschberg R. Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol. 2006 Sep;17(9):2504-12. Epub 2006 Aug 9.
Wang S, Hirschberg R. Y-box protein-1 is a transcriptional regulator of BMP7. J Cell Biochem. 2011 Apr;112(4):1130-7. doi: 10.1002/jcb.23027.