Xiaohui Li, MD, MSc
Investigator, The Lundquist Institute
Associate Professor of Pediatrics, David Geffen School of Medicine at UCLA
Research DescriptionDr. Li provides statistical support for a variety of genetic approaches and data, including linkage, genome-wide association, sequencing and Omics studies.
Her research is focused on two major areas: ophthalmologic genetics and pharmacogenetics. Dr. Li leads comprehensive genetic analysis designs and methodologies for several eye-related diseases, such as keratoconus, diabetic retinopathy, age-related macular degeneration, myopia, retinal vasculature, and retinopathy of prematurity. For the pharmacogenetics area, Dr. Li serves as the lead genetic analyst of various treatments response to different disorders/traits, such as lipids, blood pressure, electrocardiogram (ECG) traits, and cardiovascular events.
- MS, 2004, Biostatistics University of California, Los Angeles
- MD, 1995, Medicine, Beijing Medical University, China
Recent and/or Significant Publications
Li X, Bykhovskaya Y, Haritunians T ... Rabinowitz YS. A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries. Hum Mol Genet. 2012;21(2):421-429.PubMed ID: 21979947, PubMed Central ID: 3276283;
Wei W-Q, Li X, Feng Q … Denny JC. LPA gene variants are associated with residual cardiovascular risk in patients receiving statins. Circulation. 2018;138(17):1839-1849. PubMed ID: 29703846; PubMed Central ID: 6202211;
Hardcastle AJ, Liskova P, Bykhovskaya Y … Li X … Hysi PG. A multi-ethnic genome-wide association study implicates collagen matrix integrity and cell differentiation pathways in keratoconus. Commun Biol. 2021;4(1):266. PubMed ID: 33649486; PubMed Central ID: 7921564;
Postmus I, Trompet S… Li X … Caulfield MJ. Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins. Nat Commun. 2014;28(5):5068. PubMed ID: 25350695; PubMed Central ID: 4220464;
R. de las Fuentes L, Sung YJ, Sitlani CM ...Li X … Whitsel EA. Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry. Pharmacogenomics J. 2020;20:482–493. PubMed ID: 31806883; PubMed Central ID: 7260079;