Yan He Lue, MD
Investigator, The Lundquist Institute
Professor of Medicine, David Geffen School of Medicine at UCLA
1) the cellular and molecular mechanisms of hormonal regulation of spermatogenesis; 2) fertility preservation for men with congenital and acquired testis failure using animal models and stem cell technology; 3) male contraceptive development
Research DescriptionDr. Lue's research has demonstrated that: 1) testicular hyperthermia induces male infertility by increased germ cell apoptosis; 2) progestins mediated through the progesterone receptors have direct inhibitory actions on spermatogenesis; 3) Humanin and IGFBP-3 have opposing effects in the regulation of spermatogenesis; 4) Humanin, a small peptide from mitochondria, protects germ cells from damage induced by testicular hormonal deprivation, hyperthermia or chemotherapeutic agents; 5) XXY mouse is an experimental model for men with Klinefelter syndrome, which can be used to investigate the effect of over-expression of X-linked genes on spermatogonial stem cells and test therapeutic strategy for fertility preservation.
- MD, 1993, Shandong University School of Medicine
Recent and/or Significant Publications
Lue Y, Gao C, Swerdloff R, Hoang J, Avetisyan R, Jia Y, Rao M, Ren S, Atienza V, Yu J, Zhang Y, Chen M, Song Y, Wang Y, Wang C. Humanin analog enhances the protective effect of dexrazoxane against doxorubicin-induced cardiotoxicity. Am J Physiol Heart Circ Physiol. 2018 Sep 1;315(3):H634-H643. doi: 10.1152/ajpheart.00155.2018. Epub 2018 May 18. PMID: 29775411; PMCID: PMC6734085.
Jia Y, Yee JK, Wang C, Nikolaenko L, Diaz-Arjonilla M, Cohen JN, French SW, Liu PY, Lue Y, Lee WP, Swerdloff RS. Testosterone protects high-fat/low-carbohydrate diet-induced nonalcoholic fatty liver disease in castrated male rats mainly via modulating endoplasmic reticulum stress. Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E366-E376. doi: 10.1152/ajpendo.00124.2017. Epub 2017 Sep 19. PMID: 28928235; PMCID: PMC5966753.
Jia Y, Lue Y, Swerdloff RS, Lasky JL, Panosyan EH, Dai-Ju J, Wang C. The humanin analogue (HNG) prevents temozolomide-induced male germ cell apoptosis and other adverse effects in severe combined immuno-deficiency (SCID) mice bearing human medulloblastoma. Exp Mol Pathol. 2019 Aug;109:42-50. doi: 10.1016/j.yexmp.2019.104261. Epub 2019 May 11. PMID: 31085184; PMCID: PMC6680022.
Deebel NA, Galdon G, Zarandi NP, Stogner-Underwood K, Howards S, Lovato J, Kogan S, Atala A, Lue Y, Sadri-Ardekani H. Age-related presence of spermatogonia in patients with Klinefelter syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2020 Jan 1;26(1):58-72. doi: 10.1093/humupd/dmz038. PMID: 31822886.
Yen K, Mehta HH, Kim SJ, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, Mattison JA, Buffenstein R, Breton CV, Wang C, Longo V, Atzmon G, Wallace D, Barzilai N, Cohen P. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 2020 Jun 23;12(12):11185-11199. doi: 10.18632/aging.103534. Epub 2020 Jun 23. PMID: 32575074; PMCID: PMC7343442.