Roger Lewis, MD, PhD
Investigator, The Lundquist Institute
Professor of Medicine, David Geffen School of Medicine at UCLA
Vice Chair for Academic Affairs, Department of Emergency Medicine, Harbor-UCLA Medical Center
Member, Institute of Medicine of the National Academies, Washington, DC
Project Director, Electronic Health Record Implementation, Department of Health Services, Los Angeles County, California
Senior Medical Scientist, Berry Consultants, LLC
Contact
Email
Clinical research methodology
Research Description
Dr. Lewis’s expertise centers on adaptive and Bayesian clinical trials, including platform trials; translational, clinical, health services and outcomes research; interim data analysis; data monitoring committees; and informed consent in emergency research studies. These clinical trial designs use the incoming stream of information that exists during the conduct of a clinical trial to trigger changes in key clinical trial characteristics to improve the ethical balance, statistical efficiency, or scientific value of the trial relative to a fixed, non-adaptive trial design.Theme Groups
Education
- PhD, 1986, Stanford University
- MD, 1987, Stanford University School of Medicine
Recent and/or Significant Publications
Meurer WJ, Lewis RJ, Berry DA. Adaptive clinical trials: a partial remedy for the therapeutic misconception? JAMA. 2012; 307(22):2377-8. PubMed [journal] PMID: 22692168
Lewis RJ, Angus DC, Laterre PF, Kjølbye AL, van der Meulen E, Blemings A, Graves T, Russell JA, Carlsen JE, Jacobsen K, Yealy DM. Rationale and Design of an Adaptive Phase 2b/3 Clinical Trial of Selepressin for Adults in Septic Shock. Selepressin Evaluation Programme for Sepsis-induced Shock—Adaptive Clinical Trial. Annals of the American Thoracic Society. 2018 Feb;15(2):250-7
Berry SM, Connor JT, Lewis RJ. The platform trial: an efficient strategy for evaluating multiple treatments. JAMA. 2015; 313(16):1619-20. PMID: 25799162
Lewis RJ. The pragmatic clinical trial in a learning health care system. Clin Trials. 2016; 13(5):484-92. PMID: 27365011
Quintana M, Viele K, Lewis RJ. Bayesian Analysis: Using Prior Information to Interpret the Results of Clinical Trials. JAMA. 2017 Oct 24;318(16):1605-1606. doi: 10.1001/jama.2017.15574. PubMed PMID: 29067406.