Samuel W. French, M.D.

Samuel French, MD

Investigator, The Lundquist Institute
Chief, Anatomic Pathology, Harbor-UCLA Medical Center
Distinguished Professor of Pathology, David Geffen School of Medicine at UCLA


Pathogenesis of Acute Alcoholic Hepatitis

Research Description

Dr. French is a renowned expert in pathology of the liver and one of the pioneers in establishing the nature of the liver cell cytoskeleton and the pathogenesis of Mallory bodies. His research includes the pathogenesis of alcoholic and liver disease, more specifically investigating the regulation of expression of RNA sequence genes in liver biopsies from patients with acute alcoholic hepatitis.


  • AB, 1949, University of California, Berkeley
  • MD, 1952, University of California, San Francisco

Recent and/or Significant Publications

Afifiyan N, Tillman B, French BA, Masouminia M, Samadzadeh S, French SW. Over expression of proteins that alter the intracellular signaling pathways in the cytoplasm of the liver cells forming Mallory-Denk bodies. Exp Mol Pathol. 2017 Jan 12. pii: S0014-4800(17)30016-3. doi: 10.1016/j.yexmp.2017.01.011. [Epub ahead of print] PMID: 28089901
Neuman MG, French SW, Zakhari S, Malnick S, Seitz HK, Cohen LB, Salaspuro M, Griffin AV, Barasch A, Kirpich IA, Thomes PG, Schrum LW, Donohue TM Jr, Kharbanda K, Cruz M, Opris M. Alcohol, microbiome, life style influence alcohol and non-alcoholic organ damage. Exp Mol Pathol. 2017 Jan 7. pii: S0014-4800(17)30002-3. doi: 10.1016/j.yexmp.2017.01.003. [Epub ahead of print] Review. PMID: 28077318
Masouminia M, Samadzadeh S, Ebaee A, French BA, Tillman B, French SW. Alcoholic steatohepatitis (ASH) causes more UPR-ER stress than non-alcoholic steatohepatitis (NASH). Exp Mol Pathol. 2016 Oct;101(2):201-206. doi: 10.1016/j.yexmp.2016.08.002. No abstract available. PMID: 27587085
Masouminia M, Samadzadeh S, Mendoza AS, French BA, Tillman B, French SW. Upregulation of autophagy components in alcoholic hepatitis and nonalcoholic steatohepatitis. Exp Mol Pathol. 2016 Aug;101(1):81-8. doi: 10.1016/j.yexmp.2016.07.002. PMID: 27432584