Harry Rossiter, PhD
Investigator, The Lundquist Institute
Associate Professor of Respiratory & Critical Care Physiology & Medicine, David Geffen School of Medicine at UCLA
Director of Research Training, Division of Respiratory Critical Care Physiology and Medicine, Harbor-UCLA Medical Center
Director of the UCLA-CTSI High Resolution Tissue Respirometry Core at LA BioMed
The integrative biology of exercise
Research DescriptionDr. Rossiter's research mission is to improve the lives of patients in whom exercise intolerance is a major symptom. For this he uses a range of in situ, in vivo, and computational methods to study physiological responses to exercise with special reference to chronic pulmonary diseases and pulmonary rehabilitation. His lab conducts respiratory research and clinical trials focusing on the following areas:
1) Control of oxidative phosphorylation, mitochondrial function and their contribution to metabolic health and biological aging.
2) The mechanisms of exercise intolerance, muscle fatigue and symptom limitation in health and chronic disease.
- BS, 1995, University of Birmingham, UK
- MS, 1996, King’s College, University of London, UK
- PhD, 2000, St. George’s Hospital, University of London, UK
Recent and/or Significant Publications
Adami A, Hobbs BD, McDonald ML, Casaburi R, Rossiter HB. Genetic variants predicting aerobic capacity response to training are also associated with skeletal muscle oxidative capacity in moderate-to-severe COPD. Physiol Genomics. 2018 Sep 1;50(9):688-690. doi: 10.1152/physiolgenomics.00140.2017. Epub 2018 May 25.
Adami A, Rossiter HB. Principles, insights, and potential pitfalls of the noninvasive determination of muscle oxidative capacity by near-infrared spectroscopy. J Appl Physiol. 2018 Jan 1;124(1):245-248.
Rana, A, Oliveira, MP, Khamoui, AV, Aparicio, R, Rera, M, Rossiter, HB, Walker, DW. Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nat Commun. 2017; 8: 448.
Bhatt SP, Soler X, Wang X, Murray S, Anzueto AR, Beaty TH, Boriek AM, Casaburi R, Criner GJ, Diaz AA, Dransfield MT, Curran-Everett D, Galbán CJ, Hoffman EA, Hogg JC, Kazerooni EA, Kim V, Kinney GL, Lagstein A, Lynch DA, Make BJ, Martinez FJ, Ramsdell JW, Reddy R, Ross BD, Rossiter HB, Steiner RM, Strand MJ, van Beek EJ, Wan ES, Washko GR, Wells JM, Wendt CH, Wise RA, Silverman EK, Crapo JD, Bowler RP, Han MK. COPD Gene Investigators. Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 Jul 15;194(2):178-84. doi: 10.1164/rccm.201511-2219OC.
Puente-Maestu L, Palange P, Casaburi R, Laveneziana P, Maltais F, Neder JA, O'Donnell DE, Onorati P, Porszasz J, Rabinovich R, Rossiter HB, Singh S, Troosters T, Ward S. Use of exercise testing in the evaluation of interventional efficacy: an official ERS statement. Eur Respir J. 2016 Feb;47(2):429-60. doi: 10.1183/13993003.00745-2015. Epub 2016 Jan 21.
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