Ronald Swerdloff, MD

Ronald Swerdloff, MD

Investigator, The Lundquist Institute
Chief, Division of Endocrinology, Harbor-UCLA Medical Center
Professor of Medicine, David Geffen School of Medicine at UCLA

Contact

Male Reproductive Medicine and Biology; Androgen Drug Development; Protective Effects of the Peptide Humanin

Research Description

Dr. Swerdloff’s research includes basic investigations, clinical trials, and translational studies. His research interests involve many aspects of basic male reproductive physiology and clinical reproductive investigation. Ongoing work includes the regulation of spermatogenesis, regulation of the androgen receptor gene, neuroregulation of gonadotropin secretion, development of male contraceptive agents, pharmacology of androgen hormones, regulation of spermatogenesis hormonal function in the testis, ethnic differences in the reproductive endocrine system, role of 5-alpha reduced androgens in the prevention and treatment of cognitive dysfunction, sexual dysfunction, impaired vitality, osteoporosis and frailty in elderly men, factors influencing male fertility, molecular basis and neurobiology of cognitive dysfunction in Klinefelter's Syndrome, sex steroid effects on cognition and neurodegenerative disorders, and mutant mouse models in reproductive biology, stem cell transplantation in the testes. Recent studies involve protection of normal tissue from the adverse effects of chemotherapy including onco-infertility, granulocytopenia, alopecia, brain dysfunction and cardiotoxicity.
Theme Groups

Education

  • MD, 1962, University of California, San Francisco

Recent and/or Significant Publications

Jia Y, Yee JK, Wang C, Nikolaenko L, Cohen J, French S, Lue YH, Lee WN, Swerdloff RS. Testosterone and Non-Alcoholic Fatty Liver Disease--Friend or Foe, Endo2017 Florida April 2017.
Lue YH, Mehta H, Hoang J,Yen K, Wan JX, Swerdloff RS, Cohen P, Wang C, Division of Endocrinology, LABioMed at Harbor-UCLA; USC, Leonard Davis School of Gerontology, University of Southern, California, Los Angeles, CA. Humanin Transgenic Mice are Protected from Yclophosphamide-Induced Male Germ Cell Apoptosis. ASA American Society of Andrology Testis Workshop Florida April 2017.
Galdon G, Zarandi NP, Lue YH, Swerdloff RS, Kogan S, Sadri-Ardekani H, Atala A, Wake Forest Institute for Regenerative Medicine Division of Endocrinology, Harbor-UCLA Medical Center Department of Medicine and Los Angeles Biomedical Research Institute, Wake Forest School of Medicine Department of Urology. In Vitro Culture of Klinefelter Mouse Spermatogonial Stem Cells. ASA American Society of Andrology Testis Workshop Florida April 2017.
Wu S, Yuen F, Swerdloff RS, Pak YJ, Liu PY, Bremner WJ, Page ST, Wang C. Single Escalating Dose Pharmacokinetics, Safety, and Food Effects of a New Oral Androgen 11β-Methyle-19-Nortestosterone 17β-Dodecylcarbonate in Man: A Potential Male Hormonal Contraceptive. Western Medical Regional Conference, September 25, 2017.
Yuen F, Wu S, Thirumalai A, Swerdloff RS, Page ST, Liu PY, Dart C, Wu H, Blithe DL, Sitruk-Ware R, Long J, Bai F, Hull L, Bremner WJ, Anawalt BD, Wang C. Preventing secondary exposure to women from men applying a novel nestorone/testosterone contraceptive gel. Andrology. 2019 Mar;7(2):235-243.

Videos

Ronald Swerdloff MD Discusses Chemotherapy Side Effects