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Our Scientific Leadership

Innovation Hub Executive Directors

Each Innovation Hub is led by two Executive Directors serving in complementary roles along the translational continuum, one with expertise in clinical and translational research and one with a biomedical research background. Together, they serve as stewards, connectors, and champions for their Hub, bridging bench and bedside while preserving investigator autonomy and scientific freedom.

Paul Mathews, PhD

Executive Director

Lynda Polgreen, MD, MS

Executive Director

Advanced Therapeutics & Biomedical Technologies 

We are focused on turning scientific discovery into real progress for patients. Across the Hub, investigators are developing next-generation therapies, advanced  genomics and AI-enabled diagnostics, and innovative medical technologies to address complex diseases. From regenerative medicine and stem cell science to precision therapeutics and device innovation, we are working to move promising ideas from the laboratory toward the clinic, with the goal of creating meaningful new options for patients and families.

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Rajesh K. Garg, MD

Executive Director

Harry B. Rossiter, PhD

Executive Director

Systems Medicine & Precision Prevention

We are focused on preventing disease before it takes hold. By combining insights from biology, physiology, and clinical medicine, investigators work to better understand the complex systems that drive chronic disease – including cardiovascular, lung, metabolic, and kidney diseases – and the mechanisms underlying exercise intolerance across diverse clinical and real-world settings.

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Jessica A. Keeley, MD, FACS

Executive Director

Mohsen Saidinejad, MD, MS

Executive Director

Translation Science & Population Health 

We are focused on ensuring that scientific discovery leads to better health in the real world. Investigators partner closely with clinicians and communities to translate research into improved care, expand access to proven treatments, and strengthen health outcomes across diverse populations. By connecting discovery with everyday healthcare, we help ensure that innovation reaches the patients and communities who need it most.

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Ashraf S. Ibrahim, PhD

Executive Director

Delphine J. Lee, MD, PhD, FAAD

Executive Director

Infectious Diseases & Immunology

We are focused on addressing some of the world’s most urgent health challenges. Researchers study how infections and the immune system shape diseases ranging from emerging pathogens to cancer and autoimmune conditions. Our work includes developing vaccines, new antimicrobial therapies, and immune-based treatments designed to protect vulnerable populations and strengthen global health. 

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Institute Executive Officers

Institute Executive Officers are senior scientific stewards who work horizontally across the organization, connecting Investigators, Hubs, Centers, and infrastructure. They set direction, reduce fragmentation, and increase effectiveness across TLI’s most important mission-critical functions.

Denise Al Alam, PhD, ATSF

Executive Resource Integration Officer

Oversees scientific strategy for shared research cores and infrastructure; identifies emerging equipment and technology needs. 

Eric Daar, MD

Executive Medical Officer

Provides scientific leadership for clinical research and clinical trials strategy; accelerates translation from discovery to human studies.

Scott Filler, MD

Executive Career Training Officer

Provides scientific leadership for training, mentorship, and career development; coordinates with Hubs to strengthen the investigator pipeline. 

Loren Miller, MD, MPH

Executive Community Engagement Officer

Leads strategy for community-centered research and population health; serves as liaison to community advisory structures.

Jerome Rotter, MD

Executive Data Science Officer

Guides development of data science, AI, and computational research infrastructure; promotes integration of computational approaches across Hubs.

Michael Yeaman, PhD, MSc

Executive Science Officer

Oversees pilot funding strategy, team-science enablement, technology development pathways, and bench-clinical collaboration. 

Leadership News

From organizational announcements and key appointments to strategic updates, learn about our leadership’s ongoing commitment to fostering innovation and positioning the Institution for long-term success in a rapidly evolving industry landscape.

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