IL-23 receptor signaling prevents ferroptotic cell death via an unknown mechanism. 4HNE released by ferroptotic macrophages induces apoptosis, ferroptosis, necroptosis, and pyroptosis in adjacent cells.
Dr. Marc Swidergall’s paper, “IL-23 signaling prevents ferroptosis-driven renal immunopathology during candidiasis,” has been published in Nature Communications. The paper, published online on September 22, covers research by Dr. Swidergall and his colleagues on Candida infection and inflammation and how ferroptotic cell death presents a new avenue to tackle the infection. They report that recognition of the fungal cell wall component β-glucan promotes renal immunopathology by reducing the cytokine IL-23 during disseminated candidiasis.
This highly prestigious ASM fellowship supports doctoral graduate students interested in the microbial sciences and who seek mentorship in navigating their career trajectory. Barbarino and Alqarihi were selected from a pool of thousands of applicants for this esteemed ASM Fellowship. They will be mentored for the year by seven highly accomplished mentors in various areas of microbiology.
ATS (American Thoracic Society) gives this award to a mid-career candidate who is recognized for achievements in research, mentorship, clinical care, education, advocacy, or scholarship.
Dr. Al Alam received this award as a recognition for her numerous contributions to pediatric pulmonary research, mentorship and advocacy. Her research focuses on understanding how progenitor cells of the human lung decide what mature cell type to become and when; and how these decisions are affected by congenital anomalies and prematurity. She is a pioneer in the field of human lung development and made seminal discoveries describing a novel progenitor cell population in the human developing lung.
Funding will be directed to TLI’s Institute of Respiratory Medicine and Exercise Physiology with a Research Focus on Diverse and Underserved Patient Populations
LOS ANGELES (May 31, 2022) — The Lundquist Institute has announced that it has received a grant of $112,000 from the Johnny Carson Foundation to support the training of the next generation of chronic obstructive pulmonary disease (COPD) researchers at its Institu
Beatson Foundation award may help develop a novel technology to generate an infinite supply of insulin producing cells
Eiji Yoshihara, Ph.D., Investigator at The Lundquist Institute, has received a two-year, $220,000 grant from the Beatson Foundation for a proposed study to investigate how human pancreatic β cells, responsible for making insulin in the body, achieve long-term survival and proliferation.
ERRγ deletion causes rapid and progressive pancreatic atrophy
H&E staining (upper panel) and Masson’s trichrome staining (middle panel) of pancreas from control (CON) and ERRγ conditional Knock-out (cKO) cKO mice 7d after the ERR γ deletion.
Gross images of pancreas (lower panel)
We are doing this study to find out why kids with MPS have problems with their bones, joints, brains, and other parts of their body so we can come up with medications that help them.
The Study: This research study collects blood samples from healthy children and adolescents to support research on MPS (Mucopolysaccharidoses), an inherited disease caused by the body’s inability to produce specific enzymes. The missing or insufficient enzyme prevents cells from recycling waste, resulting in cells not working right throughout the body.
The non-invasive delivery device will be for use in respiratory distress syndrome (RDS), a significant cause of neonatal mortality and morbidity
The Lundquist Institute’s investigator Frans Walther, MD, PhD, has received a two-year grant from the Bill & Melinda Gates Foundation in the amount of $471,858.00 to support the development of a synthetic aerosolized lung surfactant and a non-invasive delivery device for use in infant respiratory distress syndrome (RDS), a significant cause of neonatal mortality and morbidity. Newborns experiencing RDS must dramatically increase the effort to take each breath, due to lack of adequate, naturally occurring surfactant production in their lungs.
JDRF Career Development Awards are highly competitive and given to only a few promising junior researchers each year
The Lundquist Institute’s investigator Eiji Yoshihara, Ph.D., has received a five-year $749,995.50 Career Development Award from JDRF (formerly known as Juvenile Diabetes Research Foundation) for his proposed study on how human β cells gain immune evasive function by environmental cues. In pre-clinical humanized models, induction of immune-evasive function in stem cell derived functional human islet-like oganoids has proven to cure diabetes by reducing the risk of graft rejection.
Jody Spillane, Sr. VP for Public Affairs, Spearheads New Program to Introduce Elementary School Students to Science
LOS ANGELES (February 24, 2022) — The Lundquist Institute today has launched an exciting new program that introduces elementary public-school students to science. The new Institute initiative began offering its science-based curriculum to elementary school students in December of 2021 and will extend its workshops through June 2022 and then continue to offer the program every semester going forward.