Yan Group’s Research Shows That Motile Cilia Are Key to Oocyte Pickup in the Fallopian Tube
Unlike the normal Fallopian tube (left), the "cilia-less" Fallopian tube fails to pick up ovulated eggs, leading to female infertility (right). Art by Tingting Xie.
LOS ANGELES — Today, The Lundquist Institute announced that Wei Yan, MD, PhD, and his research group have solved a longstanding mystery and scientific debate about the mechanism underlying the gamete and embryo transport within the Fallopian tube. Using a mouse model where the animals lacked motile cilia in the oviduct, Dr.
Dr. Ibrahim’s start-up Vitalex Biosciences is manufacturing humanized monoclonal antibodies that would stem the spread of this fatal disease
LOS ANGELES — The Lundquist Institute today announced that one of its spinoff start-up companies, Vitalex Biosciences, founded by researcher Dr. Ashraf Ibrahim, is producing an antibody that stems the spread of mucormycosis, a deadly fungal infection with an overall mortality rate of 50% and higher. Mucormycosis is an emerging infection caused by exposure to mucor, a mold commonly found in soil, plants, manure, and decaying fruits and vegetables.
COVID Research Supports The Institute’s Core Mission to Save Lives and Empower Healthcare Equity
LOS ANGELES, CA — April 27, 2021 — Investigators at The Lundquist Institute at Harbor-UCLA Medical Center, a leading clinical research center on life-saving vaccines and treatments, have been among the first and foremost to respond against COVID-19. Since March 2020, The Lundquist Institute has led or participated in eight COVID-19 clinical studies and the results of this research have changed the world. This timely and vigorous response was due to the number of early cases and extreme COVID-19 infection surges in south-central Los Angeles.
Matthew Budoff, MD, Will Present the Analyses at the European Society of Cardiology (ESC) Preventive Cardiology 2021
LOS ANGELES (April 17, 2021) — Today, The Lundquist Institute announced that Matthew Budoff, MD, Director of Cardiovascular CT at the Institute and Professor of Medicine at the David Geffen School of Medicine at UCLA, will present further analyses from the Effect of Icosapent Ethyl on Progression of Coronary Atherosclerosis in Patients with Elevated Triglycerides on Statin Therapy: EVAPORATE Trial as Late- Breaking Science at European Society of Cardiology (ESC) Preventive Cardiology 2021, the Annual Congress of the European Association of Preventive Cardiology.
For Critically Ill Patients with Advanced Medical Illnesses and Poor Prognoses, Overuse of Invasive ICU Treatment May Prolong Suffering
LOS ANGELES (April 13, 2021) — The Lundquist Institute (TLI) Investigator Dong W. Chang, MD, and his colleagues’ study on critically ill patients and ICU treatments was published in JAMA Internal Medicine. The study – “Evaluation of Time-Limited Trials Among Critically Ill Patients with Advanced Medical Illnesses and Reduction of Nonbeneficial ICU Treatments” – found that training physicians to communicate with family members of critically ill patients using a structured approach, which promotes shared decision-making, improved the quality of family meetings.
Bill & Melinda Gates Medical Research Institute To Develop Formulation
-Agreement advances evolution of synthetic lung surfactants to treat respiratory distress Syndrome in premature infants in Low- and Middle-Income Countries-
LOS ANGELES — The Lundquist Institute (TLI) and The Bill & Melinda Gates Medical Research Institute (Gates MRI) executed a license agreement for TLI intellectual property covering a synthetic lung surfactant formulation to be developed for respiratory distress syndrome (RDS) for premature infants in Low- and Middle-Income countries (LMIC). TLI already maintains patents on this invention in the United States, Canada and Europe.
The Lundquist Institute researchers discovered a natural compound that exhibits almost ideal male contraceptive effects in pre-clinical studies
LOS ANGELES — In a new paper published by Nature Communications, The Lundquist Institute (TLI) Investigator Wei Yan, MD, PhD, and his research colleagues spell out an innovative strategy that has led to the discovery of a natural compound as a safe, effective and reversible male contraceptive agent in pre-clinical animal models. Despite tremendous efforts over the past decades, the progress in developing non-hormonal male contraceptives has been very limited.
The grant will fund clinical trials to study the efficacy of psilocybin in treating the emotional suffering associated with terminal medical illness
LOS ANGELES — The Lundquist Institute has received a $1.75 million grant from the Steven & Alexandra Cohen Foundation to fund a multi-site clinical trial to evaluate the efficacy and safety of the compound psilocybin in individuals with severe psychological distress associated with a terminal medical illness. The grant will also support education and outreach programs related to the use of psilocybin within the field of palliative care.
Amgen Golden Ticket Winners to Receive Lab Space, Mentoring and Other Benefits
THOUSAND OAKS, Calif. – Amgen (NASDAQ:AMGN) today announced a three-year, Golden Ticket sponsorship of the BioLabs LA at The Lundquist Institute (TLI) life sciences co-working space to accelerate the development of new therapies, medical devices, and diagnostics to advance and improve human health. The BioLabs at TLI shared laboratory space was created to help high-potential life science and biotech startups overcome key obstacles for many early stage organizations, including: access to laboratory infrastructure, programming, and business development mentorship.
Ashraf S. Ibrahim, PhD, Lead Author, on publication in the world’s No. 1 Scientific Journal for Microbiology
LOS ANGELES — Today Nature Microbiology publishes The Lundquist Institute Investigator Dr. Ashraf Ibrahim and his co-authors’ paper, “Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis.”